Scholarlink

<p>Monocrotophos, an organophosphate pesticide widely used, has been reported to induce the reproductive toxicity via oxidative stress and apoptosis. Thus, the current study was carried out to study the protective nature of the <i>Curcuma longa</i> on monocrotophos-induced testicular toxicity in caprine testicular cells. Monocrotophos induced a number of apoptotic features, including pyknotic nuclei, tubular degeneration, enhanced vacuolization, etc. In testicular cells, monocrotophos (100&#xa0;µM and 1000&#xa0;µM for an exposure period of 4 and 6&#xa0;h) caused a time- and dose-dependent decline in percentage viability of cells, increased incidence of apoptosis, histopathological alterations, increased MDA levels and decreased ferric reducing antioxidant (FRAP) activity. However, <i>C. longa</i> extract showed antagonistic effects in testicular tissues treated with monocrotophos, as it reduced apoptotic characteristics and histological alterations. Along with this, <i>C. longa</i> extract also decreased oxidative stress levels, as observed by lower MDA levels and increased FRAP activity. These results indicate that <i>C. longa</i> has potent antioxidant and cytoprotective properties and may serve as a potential therapeutic agent for monocrotophos-induced testicular toxicity and associated reproductive disorders.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Curcuma longa Mitigates Monocrotophos-Induced Oxidative Stress and Apoptosis in Testicular Germ Cells: Insights into Its Cytoprotective Potential

  • 期刊论文

  • 发表日期：

    2026年7月3日

查看全文
  • Vishavjeet Rathee,
  • Prerna Bikal,
  • Anshu Siwach,
  • Shalu Sharma,
  • Jitender Kumar Bhardwaj

摘要

Monocrotophos, an organophosphate pesticide widely used, has been reported to induce the reproductive toxicity via oxidative stress and apoptosis. Thus, the current study was carried out to study the protective nature of the Curcuma longa on monocrotophos-induced testicular toxicity in caprine testicular cells. Monocrotophos induced a number of apoptotic features, including pyknotic nuclei, tubular degeneration, enhanced vacuolization, etc. In testicular cells, monocrotophos (100 µM and 1000 µM for an exposure period of 4 and 6 h) caused a time- and dose-dependent decline in percentage viability of cells, increased incidence of apoptosis, histopathological alterations, increased MDA levels and decreased ferric reducing antioxidant (FRAP) activity. However, C. longa extract showed antagonistic effects in testicular tissues treated with monocrotophos, as it reduced apoptotic characteristics and histological alterations. Along with this, C. longa extract also decreased oxidative stress levels, as observed by lower MDA levels and increased FRAP activity. These results indicate that C. longa has potent antioxidant and cytoprotective properties and may serve as a potential therapeutic agent for monocrotophos-induced testicular toxicity and associated reproductive disorders.

Graphical abstract