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<p><i>Thunbergia mysorensis,</i> an ethnomedicinal plant, is reported for antioxidant, antimicrobial and antidiabetic activities<i>.</i> However, there is no information on the anti-inflammatory and cytotoxic properties of <i>T. mysorensis.</i> Also, information on the bioactive metabolites of this plant is scanty. Therefore, in the current study, anti-inflammatory, antioxidant and anti-proliferative properties of <i>T. mysorensis</i> bark and leaf samples were evaluated using in vitro studies. Additionally, an effort was undertaken to ascertain <i>T. mysorensis's</i> total phenolics and flavonoids and, to profile the bioactive compounds using HRLC-MS/MS method. The study revealed a significant (p &lt; 0.01) anti-inflammatory activity of bark methanol with a highest percentage of protein denaturation inhibition (97.5 ± 0.23%) and proteinase (86.83 ± 1.17%) activities respectively along with strong DPPH (SC<sub>50</sub> = 0.406 ± 0.02&#xa0;mg/mL) and hydroxyl (SC<sub>50</sub> = 0.072 ± 0.001&#xa0;mg/mL) radical scavenging activities as well as high FRAP value (242.08 ± 44.5&#xa0;mg/mL). However, <i>T. mysorensis</i> extracts exhibited mild antiproliferative activities against breast cancer (MCF7) cells. The presence of flavonoids (6.25 ± 0.64&#xa0;mg&#xa0;QE/g) and phenolics (4.27 ± 0.20&#xa0;mg&#xa0;GAE/g) in leaf and bark samples showed a positive correlation with the antioxidant activity. HRLC-MS/MS analysis of bark methanol identified the presence of corylin, daurioxoisoporphine B and prunasin as the major phytochemicals that might have contributed to the pharmacological potential of this plant. Therefore, the current study forms the basis for further in-depth studies on the potential use of this plant to isolate potent anti-inflammatory and antioxidant phytochemicals and its use in therapeutic and nutraceutical applications.</p>

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Anti-inflammatory, Antioxidant and Antiproliferative Activities of Thunbergia mysorensis and Profiling of Bioactive Compounds

  • 期刊论文

  • 发表日期：

    2026年3月28日

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  • K. J. Spandana,
  • N. Bhagya

摘要

Thunbergia mysorensis, an ethnomedicinal plant, is reported for antioxidant, antimicrobial and antidiabetic activities. However, there is no information on the anti-inflammatory and cytotoxic properties of T. mysorensis. Also, information on the bioactive metabolites of this plant is scanty. Therefore, in the current study, anti-inflammatory, antioxidant and anti-proliferative properties of T. mysorensis bark and leaf samples were evaluated using in vitro studies. Additionally, an effort was undertaken to ascertain T. mysorensis's total phenolics and flavonoids and, to profile the bioactive compounds using HRLC-MS/MS method. The study revealed a significant (p < 0.01) anti-inflammatory activity of bark methanol with a highest percentage of protein denaturation inhibition (97.5 ± 0.23%) and proteinase (86.83 ± 1.17%) activities respectively along with strong DPPH (SC50 = 0.406 ± 0.02 mg/mL) and hydroxyl (SC50 = 0.072 ± 0.001 mg/mL) radical scavenging activities as well as high FRAP value (242.08 ± 44.5 mg/mL). However, T. mysorensis extracts exhibited mild antiproliferative activities against breast cancer (MCF7) cells. The presence of flavonoids (6.25 ± 0.64 mg QE/g) and phenolics (4.27 ± 0.20 mg GAE/g) in leaf and bark samples showed a positive correlation with the antioxidant activity. HRLC-MS/MS analysis of bark methanol identified the presence of corylin, daurioxoisoporphine B and prunasin as the major phytochemicals that might have contributed to the pharmacological potential of this plant. Therefore, the current study forms the basis for further in-depth studies on the potential use of this plant to isolate potent anti-inflammatory and antioxidant phytochemicals and its use in therapeutic and nutraceutical applications.