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<p><i>Ficus auriculata</i>, traditionally used to treat various ailments was investigated for its therapeutic potential through phytochemical screening, antimicrobial assays, GC–MS profiling and in silico analysis. Phytochemical screening confirmed the presence of alkaloids, glycosides, phenols, tannins, flavonoids, steroids and saponins, with methanol being the most efficient solvent. The methanolic extract showed selective activity against <i>Staphylococcus aureus</i>. GC–MS identified 35 phytoconstituents, with molecular&#xa0;docking highlighting cyclotetradecanone oxime (− 5.74&#xa0;kcal/mol), 6-(3-benzyloxy-phenyl)-5-nitro-piperidin-2-one (− 5.10&#xa0;kcal/mol) and 1,2,4-cyclopentanetrione, 3-methyl- (− 4.95&#xa0;kcal/mol) as potential PBP4 inhibitors. ADMET predictions indicated diverse pharmacokinetic and safety profiles. Our findings suggest <i>F. auriculata</i> leaves as a source of promising antimicrobial leads for future drug development.</p>

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Bioactive Potential of Ficus auriculata Leaf Extract: Phytochemical Profiling, Antimicrobial Activity and Computational Analysis

  • 期刊论文

  • 发表日期：

    2026年2月2日

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  • Rajesh Kumar Shah,
  • Mouchurisha Deori,
  • Mousumi Rai,
  • Lipi Gogoi

摘要

Ficus auriculata, traditionally used to treat various ailments was investigated for its therapeutic potential through phytochemical screening, antimicrobial assays, GC–MS profiling and in silico analysis. Phytochemical screening confirmed the presence of alkaloids, glycosides, phenols, tannins, flavonoids, steroids and saponins, with methanol being the most efficient solvent. The methanolic extract showed selective activity against Staphylococcus aureus. GC–MS identified 35 phytoconstituents, with molecular docking highlighting cyclotetradecanone oxime (− 5.74 kcal/mol), 6-(3-benzyloxy-phenyl)-5-nitro-piperidin-2-one (− 5.10 kcal/mol) and 1,2,4-cyclopentanetrione, 3-methyl- (− 4.95 kcal/mol) as potential PBP4 inhibitors. ADMET predictions indicated diverse pharmacokinetic and safety profiles. Our findings suggest F. auriculata leaves as a source of promising antimicrobial leads for future drug development.