Scholarlink

<p>The increase in oxidative stress that causes damage to various biomolecules and altering enzymatic processes is associated with aging. Advanced glycation end-products (AGE) and fructosamine are formed due to various chemical transformations as stable end-stage adducts. Glycosaminoglycans (GAGs) are the main complex macromolecules of the extracellular matrix and the major structural components of proteoglycans. Ceruloplasmin is a major copper-carrying protein, and myeloperoxidase (MPO) is released extracellularly during degranulation. The present study is focused on the assessment of AGEs, fructosamine, GAGs, ceruloplasmin and MPO, along with hydroxyl (OH), nitric oxide (NO) and salicylate probe-based radical scavenging activities, which have been evaluated to be established as biomarkers for oxidative stress during aging in humans by measuring plasma samples of 85 normal healthy subjects of both sexes (48 males and 37 females) between the ages of 20 and 81&#xa0;years. The AGEs, fructosamine, ceruloplasmin, myeloperoxidase and GAGs are observed to be positively correlated, and the OH, NO and salicylate probe-based radical scavenging activities are observed to be negatively correlated with human age. This study provides an elaborate view of the status of protein glycation along with enzymatic alterations as valid biomarkers of age-dependent oxidative stress.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Plasma Advanced Glycation End-Products, Fructosamine and Glycosaminoglycans as Protein Glycation Biomarkers of Oxidative Stress During Healthy Human Aging

  • 期刊论文

  • 发表日期：

    2025年2月28日

查看全文
  • Mohammad Murtaza Mehdi

摘要

The increase in oxidative stress that causes damage to various biomolecules and altering enzymatic processes is associated with aging. Advanced glycation end-products (AGE) and fructosamine are formed due to various chemical transformations as stable end-stage adducts. Glycosaminoglycans (GAGs) are the main complex macromolecules of the extracellular matrix and the major structural components of proteoglycans. Ceruloplasmin is a major copper-carrying protein, and myeloperoxidase (MPO) is released extracellularly during degranulation. The present study is focused on the assessment of AGEs, fructosamine, GAGs, ceruloplasmin and MPO, along with hydroxyl (OH), nitric oxide (NO) and salicylate probe-based radical scavenging activities, which have been evaluated to be established as biomarkers for oxidative stress during aging in humans by measuring plasma samples of 85 normal healthy subjects of both sexes (48 males and 37 females) between the ages of 20 and 81 years. The AGEs, fructosamine, ceruloplasmin, myeloperoxidase and GAGs are observed to be positively correlated, and the OH, NO and salicylate probe-based radical scavenging activities are observed to be negatively correlated with human age. This study provides an elaborate view of the status of protein glycation along with enzymatic alterations as valid biomarkers of age-dependent oxidative stress.