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<p>The Severe Acute Respiratory Syndrome CoronaVirus 2&#xa0;(SARS-CoV-2) is the virus that causes the contagious disease and is known as coronavirus disease 2019 (COVID-19). In December 2019, the existence of the first case of COVID-19 was recorded in Wuhan city of China and the disease spread rapidly throughout the world, causing the COVID-19 pandemic. After the phase 3 trial, researchers recently reported the studies on the safety and efficacy of treatment with Molnupiravir against SARS-CoV-2 due to the urgent need to discover antiviral agents to fight COVID-19. A topological index is a mathematical tool that gives a numerical value to the molecular graph of a chemical compound and forecasts a variety of the physico-chemical, biological and structural properties of that compound. In this present research work, we are eager to examine the distance-based topological indices&#xa0;(namely, Wiener index, hyper-Wiener index, Tratch-Stankevitch-Zefirov index and Harary index) for an oral antiviral drug Molnupiravir via their standard distance-dependent mathematical formulas and alternatively via the Hosoya polynomial approach. Also, we geometrically comprehend the Hosoya polynomial and the associated distance-based topological indices. The findings can assist and motivate the researchers in the direction of analysing some additional properties of the drug and in developing new drugs to treat COVID-19 patients.</p>

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On the Hosoya Polynomial of an Oral Antiviral COVID-19 Drug Molnupiravir

  • 期刊论文

  • 发表日期：

    2026年4月18日

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  • Shibsankar Das,
  • Shikha Rai

摘要

The Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) is the virus that causes the contagious disease and is known as coronavirus disease 2019 (COVID-19). In December 2019, the existence of the first case of COVID-19 was recorded in Wuhan city of China and the disease spread rapidly throughout the world, causing the COVID-19 pandemic. After the phase 3 trial, researchers recently reported the studies on the safety and efficacy of treatment with Molnupiravir against SARS-CoV-2 due to the urgent need to discover antiviral agents to fight COVID-19. A topological index is a mathematical tool that gives a numerical value to the molecular graph of a chemical compound and forecasts a variety of the physico-chemical, biological and structural properties of that compound. In this present research work, we are eager to examine the distance-based topological indices (namely, Wiener index, hyper-Wiener index, Tratch-Stankevitch-Zefirov index and Harary index) for an oral antiviral drug Molnupiravir via their standard distance-dependent mathematical formulas and alternatively via the Hosoya polynomial approach. Also, we geometrically comprehend the Hosoya polynomial and the associated distance-based topological indices. The findings can assist and motivate the researchers in the direction of analysing some additional properties of the drug and in developing new drugs to treat COVID-19 patients.