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<p>Cardiac tissue engineering uses scaffolds that optimally mimic the extracellular matrix to repair damaged heart tissue. Decellularized hibiscus leaves are assessed in this study as a sustainable plant-based scaffold that shows promise for cardiovascular use. The hierarchical microvascular architecture and cellulose framework that would normally enable cell adhesion were preserved while 92% of the native DNA was eliminated using an improved detergent-assisted decellularization process. After nine days of incubation on the substrate, cardiac fibroblasts seeded on the scaffolds showed exceptional biocompatibility, with progressive adhesion and proliferation reaching 87% ± 3% viability. Computational fluid dynamic analysis was used to give additional proof of concept for sufficiently uniform perfusion via primary to tertiary vascular channels, taking into account pulsed flow and non-Newtonian blood rheology. Hibiscus is 41% less expensive than decellularized spinach in terms of pressure drop and sheer-stress distribution, which makes it more effective hydraulically for creating perfusable cardiac structures.</p>

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Biomimetic Cardiac Scaffolds from Decellularized Hibiscus Leaves: A Green Engineering Approach

  • 期刊论文

  • 发表日期：

    2026年4月6日

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  • Roopsandeep Bammidi,
  • Sreeramulu Dowluru,
  • Kelli Durgaprasad,
  • Santhosh Kumar Dubba,
  • Sagar Yanda,
  • Ashok Naidu Vanjarapu,
  • Narsum Naidu Muddada,
  • Yugandhar Yandapalli,
  • Vamsi Ungati

摘要

Cardiac tissue engineering uses scaffolds that optimally mimic the extracellular matrix to repair damaged heart tissue. Decellularized hibiscus leaves are assessed in this study as a sustainable plant-based scaffold that shows promise for cardiovascular use. The hierarchical microvascular architecture and cellulose framework that would normally enable cell adhesion were preserved while 92% of the native DNA was eliminated using an improved detergent-assisted decellularization process. After nine days of incubation on the substrate, cardiac fibroblasts seeded on the scaffolds showed exceptional biocompatibility, with progressive adhesion and proliferation reaching 87% ± 3% viability. Computational fluid dynamic analysis was used to give additional proof of concept for sufficiently uniform perfusion via primary to tertiary vascular channels, taking into account pulsed flow and non-Newtonian blood rheology. Hibiscus is 41% less expensive than decellularized spinach in terms of pressure drop and sheer-stress distribution, which makes it more effective hydraulically for creating perfusable cardiac structures.