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<p>Precocious puberty, characterized by the premature sexual developmental onset before the age of 8 in girls and 9 in boys, has been linked with individuals developing adverse psychosocial and metabolic conditions in later life. In recent years and especially after the COVID-19 pandemic, there has been an increase in the number of early puberty cases globally and this has become a significant concern for healthcare providers. Isolated indoor confinement and home quarantine, increased electronic gadget usage, disruption of normal sleep pattern, changes in dietary intake, minimal physical activity and exposure to endocrine-disrupting chemicals are contributing risk factors in the development of precocious puberty. The gonadotropin releasing hormone-stimulation test, although being a gold standard for identifying precocious puberty, is known for its anxiety-inducing nature due to multiple pricks and blood drawings. Moreover, the unavailability of set cut-offs for basal and stimulated gonadotropin levels underscores the importance of identifying novel biomarkers which play a role in the development of this condition. This short commentary emphasizes prevalent risk factors that may contribute in the disruption of normal pubertal timing and highlights the importance of a multidisciplinary approach involving pediatric endocrinologists, geneticists, psychologists, schools and social support systems to understand the complex interplay of risk factors and develop strategies for mitigating this condition. It also highlights the importance of developing techniques that will help in the accurate distinction between the types of precocious puberty, their diagnosis and management, which may help healthcare professionals implement proper treatment strategy.</p>

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Precocious puberty: pathophysiology, contemporary issues and way forward

  • 期刊论文

  • 发表日期：

    2025年5月6日

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  • Antara A. Banerjee,
  • Swati Kashikar,
  • Sudha Rao,
  • Suchitra V. Surve

摘要

Precocious puberty, characterized by the premature sexual developmental onset before the age of 8 in girls and 9 in boys, has been linked with individuals developing adverse psychosocial and metabolic conditions in later life. In recent years and especially after the COVID-19 pandemic, there has been an increase in the number of early puberty cases globally and this has become a significant concern for healthcare providers. Isolated indoor confinement and home quarantine, increased electronic gadget usage, disruption of normal sleep pattern, changes in dietary intake, minimal physical activity and exposure to endocrine-disrupting chemicals are contributing risk factors in the development of precocious puberty. The gonadotropin releasing hormone-stimulation test, although being a gold standard for identifying precocious puberty, is known for its anxiety-inducing nature due to multiple pricks and blood drawings. Moreover, the unavailability of set cut-offs for basal and stimulated gonadotropin levels underscores the importance of identifying novel biomarkers which play a role in the development of this condition. This short commentary emphasizes prevalent risk factors that may contribute in the disruption of normal pubertal timing and highlights the importance of a multidisciplinary approach involving pediatric endocrinologists, geneticists, psychologists, schools and social support systems to understand the complex interplay of risk factors and develop strategies for mitigating this condition. It also highlights the importance of developing techniques that will help in the accurate distinction between the types of precocious puberty, their diagnosis and management, which may help healthcare professionals implement proper treatment strategy.