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Purpose <p>Malaria is a parasitic disease associated with morbidity and mortality. Severe disease, characterized by the manifestation of different pathologies, is usually associated with <i>Plasmodium falciparum</i> infection. Resistance to artemisinin derivatives, the current treatment for falciparum malaria, poses challenges. Gold nanoparticles (AuNPs) exhibit anti-inflammatory and antioxidant properties, offering therapeutic potential.</p> Methods <p>Using an experimental model of severe malaria, we assessed the impact of AuNPs on cerebral malaria, malaria-associated acute respiratory distress syndrome, and malaria-induced acute kidney injury (MAKI).</p> Results <p>As expected, infection induced blood-brain barrier dysfunction associated with brain edema and cognitive impairment. Lung damage was characterized by high inflammatory infiltrate, alveolar collapse, and high diffuse alveolar damage (DAD) score, and MAKI was revealed by impairment in functional parameters as well as markers of tubular and glomerular injury. Treatment with AuNPs increased the survival rate without changing parasitemia. Spleen size and weight were significantly decreased by the treatment. Also, there was a reduction in the CD4 + T cell population as well as a shift in splenic CD4 + T cell responses by increasing interleukin-4 production. Infection-induced brain and lung damage was prevented by the treatment; there was a reduction in cerebral edema, and the DAD score and neutrophil/lymphocyte ratio decreased. There were no changes in <i>Plasmodium berghei</i> ANKA-induced glomerular damage. However, AuNP treatment reduced tubule-interstitial injury, ameliorating proteinuria and tubular damage markers.</p> Conclusion <p>These results suggest that AuNPs can rescue mice from the effects of experimental severe malaria and provide new perspectives on novel therapeutic strategies for malaria disease.</p>

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Gold nanoparticles prevent the establishment of severe malaria in a murine animal model

  • 期刊论文

  • 发表日期：

    2025年7月24日

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  • Sarah Aparecida dos Santos Alves,
  • Douglas Esteves Teixeira,
  • Lavínia Reif Correa Oliveira,
  • Maria Eduarda Lopes Souza,
  • Monique Martins Melo,
  • Mayck Medeiros,
  • Sabrina Sodré-Serra,
  • Paticia Machado Rodrigues Silva,
  • Marco Aurélio Martins,
  • Pedro Leme Silva,
  • Patricia Rieken Macedo Rocco,
  • Celso Caruso-Neves,
  • Ana Acacia Sá Pinheiro

摘要

Purpose

Malaria is a parasitic disease associated with morbidity and mortality. Severe disease, characterized by the manifestation of different pathologies, is usually associated with Plasmodium falciparum infection. Resistance to artemisinin derivatives, the current treatment for falciparum malaria, poses challenges. Gold nanoparticles (AuNPs) exhibit anti-inflammatory and antioxidant properties, offering therapeutic potential.

Methods

Using an experimental model of severe malaria, we assessed the impact of AuNPs on cerebral malaria, malaria-associated acute respiratory distress syndrome, and malaria-induced acute kidney injury (MAKI).

Results

As expected, infection induced blood-brain barrier dysfunction associated with brain edema and cognitive impairment. Lung damage was characterized by high inflammatory infiltrate, alveolar collapse, and high diffuse alveolar damage (DAD) score, and MAKI was revealed by impairment in functional parameters as well as markers of tubular and glomerular injury. Treatment with AuNPs increased the survival rate without changing parasitemia. Spleen size and weight were significantly decreased by the treatment. Also, there was a reduction in the CD4 + T cell population as well as a shift in splenic CD4 + T cell responses by increasing interleukin-4 production. Infection-induced brain and lung damage was prevented by the treatment; there was a reduction in cerebral edema, and the DAD score and neutrophil/lymphocyte ratio decreased. There were no changes in Plasmodium berghei ANKA-induced glomerular damage. However, AuNP treatment reduced tubule-interstitial injury, ameliorating proteinuria and tubular damage markers.

Conclusion

These results suggest that AuNPs can rescue mice from the effects of experimental severe malaria and provide new perspectives on novel therapeutic strategies for malaria disease.