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<p><i>Neoehrlichia mikurensis</i> is a tick-borne bacterium that can give rise to latent infections of vascular endothelium and PMR-like symptoms. PMR is an autoinflammatory or autoimmune condition of unknown cause that has been linked to infectious agents. The objective of this study was to investigate a possible association of PMR with <i>N. mikurensis</i> infection. Patients with PMR (<i>n</i> = 142) and matched control subjects (<i>n</i> = 56) from seven primary health care centers in West Sweden were tested for infection with <i>N. mikurensis</i> by PCR and serology. Patient-reported data regarding 31 PMR symptoms, tick exposure, past and current co-morbidities were registered. Anti-endothelial cell antibodies (AECA) and 38 inflammatory markers were measured in serum. The data was analyzed by multivariate methods of pattern recognition. There was no difference in the prevalence of infection with <i>N. mikurensis</i> between the PMR patients (5.6%) and the control subjects (5.4%). PMR patients infected with <i>N. mikurensis</i> differed from the non-infected PMR patients by their raised levels of IgM AECA and of interleukin-1β, and lower levels of insulin-like growth factor-binding protein 4, cystatin C and angiopoietin-1. Furthermore, there was a correlation between IgM antibodies to <i>N. mikurensis</i> and IgM AECA (<i>r</i> = 0.50, <i>P</i> &lt; 0.0001). To conclude, PMR patients infected with <i>N. mikurensis</i> had vascular autoantibodies and a distinct inflammatory profile but whether the infection had triggered or modulated the development of PMR could not be established in the present study.</p>

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The association of Neoehrlichia mikurensis infection with polymyalgia rheumatica

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月10日

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  • Christine Lingblom,
  • Sofia Sundvall,
  • Kerstin Andersson,
  • Alaitz Aranburu,
  • Kristina Bengtsson Boström,
  • Per Hjerpe,
  • Karin Mossberg,
  • Pär-Daniel Sundvall,
  • Christine Wennerås

摘要

Neoehrlichia mikurensis is a tick-borne bacterium that can give rise to latent infections of vascular endothelium and PMR-like symptoms. PMR is an autoinflammatory or autoimmune condition of unknown cause that has been linked to infectious agents. The objective of this study was to investigate a possible association of PMR with N. mikurensis infection. Patients with PMR (n = 142) and matched control subjects (n = 56) from seven primary health care centers in West Sweden were tested for infection with N. mikurensis by PCR and serology. Patient-reported data regarding 31 PMR symptoms, tick exposure, past and current co-morbidities were registered. Anti-endothelial cell antibodies (AECA) and 38 inflammatory markers were measured in serum. The data was analyzed by multivariate methods of pattern recognition. There was no difference in the prevalence of infection with N. mikurensis between the PMR patients (5.6%) and the control subjects (5.4%). PMR patients infected with N. mikurensis differed from the non-infected PMR patients by their raised levels of IgM AECA and of interleukin-1β, and lower levels of insulin-like growth factor-binding protein 4, cystatin C and angiopoietin-1. Furthermore, there was a correlation between IgM antibodies to N. mikurensis and IgM AECA (r = 0.50, P < 0.0001). To conclude, PMR patients infected with N. mikurensis had vascular autoantibodies and a distinct inflammatory profile but whether the infection had triggered or modulated the development of PMR could not be established in the present study.