Scholarlink

Background <p>Bartonella <i>henselae</i> infection is traditionally associated with self-limited cat-scratch disease but may occasionally present with severe systemic manifestations. </p> Case presentation <p>&#xa0;We report a 43&#xa0;year-old immunocompetent man who developed a multisystem thrombo-inflammatory syndrome with thrombocytopenia, renal involvement, thrombotic events, ocular ischemia, and transient lupus anticoagulant positivity, initially suggestive of catastrophic antiphospholipid syndrome. Extensive investigations were unrevealing until whole blood PCR detected <i>B. henselae.</i> Retrospective histopathology revealed small-vessel endothelial injury compatible with microangiopathy. Doxycycline therapy was followed by clinical improvement, normalization of platelet counts, and resolution of thrombotic manifestations</p> Conclusion <p>This case highlights the diagnostic complexity of systemic Bartonella infection and the need to consider infectious triggers in unexplained thrombo-inflammatory presentations, even in immunocompetent individuals.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Bartonella henselae infection associated with a multisystemic thrombo-inflammatory syndrome in an immunocompetent adult

  • 期刊论文

  • 发表日期：

    2026年4月15日

查看全文
  • Giovanni Gobbo,
  • Marco Zacchia,
  • Federico Nalesso,
  • Marny Fedrigo,
  • Stefano Da Pozzo,
  • Luca Frison,
  • Fabrizio Vianello,
  • Annalisa Angelini,
  • Paolo Simioni,
  • Ariela Hoxha

摘要

Background

Bartonella henselae infection is traditionally associated with self-limited cat-scratch disease but may occasionally present with severe systemic manifestations.

Case presentation

 We report a 43 year-old immunocompetent man who developed a multisystem thrombo-inflammatory syndrome with thrombocytopenia, renal involvement, thrombotic events, ocular ischemia, and transient lupus anticoagulant positivity, initially suggestive of catastrophic antiphospholipid syndrome. Extensive investigations were unrevealing until whole blood PCR detected B. henselae. Retrospective histopathology revealed small-vessel endothelial injury compatible with microangiopathy. Doxycycline therapy was followed by clinical improvement, normalization of platelet counts, and resolution of thrombotic manifestations

Conclusion

This case highlights the diagnostic complexity of systemic Bartonella infection and the need to consider infectious triggers in unexplained thrombo-inflammatory presentations, even in immunocompetent individuals.