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<p>A Siberian woman in her forties presented to a public hospital in northeastern Germany with chronic back pain and a paravertebral mass, initially misdiagnosed as spinal tuberculosis. Repeated biopsies and metagenomic next-generation sequencing (mNGS) ultimately confirmed vertebral alveolar echinococcosis. Haplotype analysis revealed a novel Asian-cluster variant, supporting the presumed origin of infection.</p>

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Unmasking the mimic: vertebral alveolar echinococcosis diagnosed by metagenomic next-generation sequencing

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月21日

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  • Tassilo Kruis,
  • Marion Wassermann,
  • Barbara Graf,
  • Katharina Lührig,
  • Peter Menzel,
  • Rolf Schwarzer,
  • Johannes Ziegler,
  • Caroline Isner

摘要

A Siberian woman in her forties presented to a public hospital in northeastern Germany with chronic back pain and a paravertebral mass, initially misdiagnosed as spinal tuberculosis. Repeated biopsies and metagenomic next-generation sequencing (mNGS) ultimately confirmed vertebral alveolar echinococcosis. Haplotype analysis revealed a novel Asian-cluster variant, supporting the presumed origin of infection.