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Introduction <p>Carbapenem-resistant Enterobacterales (CRE) intestinal colonization is a key risk factor for subsequent infection. The composition of the intestinal microbiota is likely to play a role in the colonization. The aim of the study was to compare the gut microbiota composition between colonised (Col) patients and decolonised (DeCol) patients.</p> Methods <p>Patients were identified from a database of CRE colonised patients. They were categorized as either currently Col or having spontaneously DeCol. Baseline characteristics and survival in the following year after the gut microbiota characterization were also collected. Gut microbiota composition was analysed.</p> Results <p>A total of 37 patients were included: 14 in the Col group and 23 in the DeCol group. No significant differences in terms of age, BMI, sex, KATZ index, toxics, diet and comorbidity were observed. Previous hospital admission and infections caused by CRE and/or other microorganisms were more frequent in the Col group. During the 12-month follow-up, mortality was higher in the Col group (Col 43% vs. DeCol 9%, <i>p</i> = 0.035). Differences in beta diversity were observed according to Col status (Bray Curtis distance, PERMANOVA, <i>p</i> = 0.013) but not according to recent antibiotic treatment or hospital admission. <i>Suterella</i>,<i> Roseburia faecis and Eubacterium ventriosum</i>were enriched in DeCol patients. CRE colonisation was associated with a higher abundance of <i>Ruthenibacterium lactatiformans</i>.</p> Conclusions <p>The composition of faecal microbiota was different between patients with ongoing CRE colonisation and those who achieved decolonisation. Further studies are needed to assess if specific bacterial taxa could be a marker of a longer colonisation risk.</p>

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Fecal microbiota composition and clinical characteristics of patients with carbapenem-resistant enterobacterales colonization vs. patients with spontaneous decolonization

  • 期刊论文

  • 发表日期：

    2025年10月31日

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  • O. Lima,
  • S. Pérez-Castro,
  • C. Davina-Nunez,
  • M. Represa,
  • P. Rubiñán,
  • M. Ávila-Nuñez,
  • A. Filgueira,
  • C. Portela,
  • B. Sopeña,
  • MT. Pérez-Rodríguez

摘要

Introduction

Carbapenem-resistant Enterobacterales (CRE) intestinal colonization is a key risk factor for subsequent infection. The composition of the intestinal microbiota is likely to play a role in the colonization. The aim of the study was to compare the gut microbiota composition between colonised (Col) patients and decolonised (DeCol) patients.

Methods

Patients were identified from a database of CRE colonised patients. They were categorized as either currently Col or having spontaneously DeCol. Baseline characteristics and survival in the following year after the gut microbiota characterization were also collected. Gut microbiota composition was analysed.

Results

A total of 37 patients were included: 14 in the Col group and 23 in the DeCol group. No significant differences in terms of age, BMI, sex, KATZ index, toxics, diet and comorbidity were observed. Previous hospital admission and infections caused by CRE and/or other microorganisms were more frequent in the Col group. During the 12-month follow-up, mortality was higher in the Col group (Col 43% vs. DeCol 9%, p = 0.035). Differences in beta diversity were observed according to Col status (Bray Curtis distance, PERMANOVA, p = 0.013) but not according to recent antibiotic treatment or hospital admission. Suterella, Roseburia faecis and Eubacterium ventriosumwere enriched in DeCol patients. CRE colonisation was associated with a higher abundance of Ruthenibacterium lactatiformans.

Conclusions

The composition of faecal microbiota was different between patients with ongoing CRE colonisation and those who achieved decolonisation. Further studies are needed to assess if specific bacterial taxa could be a marker of a longer colonisation risk.