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Purpose <p>During fall 2021, children’s hospitals in Germany faced a surge in RSV-related hospitalizations, whereas during fall/winter 2022–2023, RSV and influenza infections both led to increased inpatient admissions. Our study prospectively assessed severe acute respiratory infections, their causative pathogens, and the resulting disease burden on German children's hospitals for the fall/winter 2023–2024 season.</p> Methods <p>From October 3, 2023 through April 16, 2024, children hospitalized with ARI as a primary diagnosis were monitored via a national survey established by the German Society for Pediatric Infectious Diseases (DGPI). Weekly data was collected on total hospital admissions, ARI-related admissions by pathogen (SARS-CoV-2, RSV, influenza, other), ICU admissions with ARI as a primary diagnosis, and respiratory support.</p> Results <p>Overall, 23% of German children's hospitals (77/334 centers) submitted 1234 survey reports. ARI-related hospital admissions surged starting in November 2023 and peaked in late December 2023 (53.4% of all admissions), in parallel with a peak in the average number of newly-admitted patients (aNA) with RSV (2.5 aNA). In comparison to the 2022/2023 season, fewer newborns and infants were admitted for ARI (4.7%, p &lt; 0.001/1.9%, p = 0.05) and fewer required ICU treatment (5.3%, p = 0.02/5.6%, p = 0.001 respectively). In 74.9% of ICU patients, ventilation support was required—9.1% less than in the previous season.</p> Conclusion <p>The clinical burden on pediatric hospitals and ICUs is strongly influenced by the changing, annually circulating pathogens and affected age group. Therefore, a continuous, systematic, dynamic collection of ARI data is critical for assessing the ARI-related morbidity and the associated burden on health care systems.</p>

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Persistently high burden of acute respiratory infections requiring hospitalization in German pediatric hospitals, fall/winter 2023–2024

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  • 发表日期：

    2025年3月11日

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  • Svenja Dreßen,
  • Josephine Schneider,
  • Maren Doenhardt,
  • Natalie Diffloth,
  • Tobias Tenenbaum,
  • Dominik T. Schneider,
  • Andreas Trotter,
  • Nicole Toepfner,
  • Reinhard Berner,
  • Tobias Ankermann,
  • Felicitas Anselmino,
  • Stefan Arens,
  • Sven Armbrust,
  • Volker Arpe,
  • Elisabeth Bach,
  • Gerald Beier,
  • Christiane Bell,
  • Martin Berghäuser,
  • Malte Bergmann,
  • Sonja Bernlochner,
  • Alexander Bey,
  • Anke Beyersdorff,
  • Julia Blumör,
  • Jasmin Brühler,
  • Reinhard Bullmann,
  • Reimer Conzelmann,
  • Roland Degener,
  • Catharina Dobberschütz,
  • Thomas Eckardt,
  • Torsten Ehrchen,
  • Christoph Ehrsam,
  • Matthias Endmann,
  • Florian Epple,
  • Michael Fedlmeier,
  • Holger Freymann,
  • Marianne Funken,
  • Marie Gah,
  • Viola Gerstmann,
  • Christine Goletz,
  • Tatiana Görhardt,
  • Katrin Gröger,
  • Julia Handermann,
  • Madeleine Haug,
  • Solvej Heidtmann,
  • Maik Heine,
  • Matthias Henschen,
  • Alexander Herz,
  • Mirjam Höfgen,
  • Daniel Hubert,
  • Birte Hunfeld,
  • Conny Huster,
  • Katja Hüwe,
  • Kristin Jähnert,
  • Daniela Jerzyk,
  • Petra Kaiser-Labusch,
  • Marcus Kania,
  • Jens Kästner,
  • Margit Kellerer,
  • Svetlana Kelzon,
  • Chrisoph Kemen,
  • Matthias Kettwig,
  • Alexander Kiefer,
  • Karoline Kinkelin,
  • Andreas Klein,
  • Christoph Klein,
  • Anna-Lisa Kleinmaier,
  • Katharina Kliemann,
  • Jan Knechtel,
  • Felix Knirsch,
  • Louise Kobelt,
  • Barbara Korinth,
  • Ekaterini Kougioumtzi,
  • Georgia Koukli,
  • Benno Kretzschmar,
  • Johannes Kugler,
  • Miriam Landauer,
  • Alfred Längler,
  • Tina Liebscher,
  • Vanessa Lionetti,
  • Daniela Lubitz,
  • Anna-Lena Lubojanski,
  • Sa Luo,
  • Julia Lutsch,
  • Friederike Mattay,
  • Anja Mayer,
  • Miriam Meusel,
  • Ulf Meyer,
  • Marko Mohorovicic,
  • Johanna Mösler-Tuczek,
  • Annika Müller,
  • Sven Nipken,
  • Ursula Pindur,
  • Erika Plattner,
  • Simone Pötzsch,
  • Lutz Pross,
  • Andreas Rößlein,
  • Meike Rumpf,
  • Jörn Schamell,
  • Norbert Schmeja,
  • Juliane Schmid,
  • Dominik Schneider,
  • Julia Schönherr,
  • Peter Schonhoff,
  • Maria Sichardt,
  • Daniel Steer,
  • Detlef Stein,
  • Frank Stemberg,
  • Julia Tabatabai,
  • Norbert Teig,
  • Wolfgang Thomas,
  • Renate Turan,
  • Vanda Tuxhorn,
  • Mirjam Ungerechts,
  • Christian v. Schnakenburg,
  • Alijda Ingeborg van den Heuvel,
  • Noemi Vereb,
  • Simone Wagner,
  • Sarah Wiehl,
  • Christiane Maria Wiethoff,
  • Elisabeth Wittig,
  • Anne Zeller,
  • Ulrich Zügge

摘要

Purpose

During fall 2021, children’s hospitals in Germany faced a surge in RSV-related hospitalizations, whereas during fall/winter 2022–2023, RSV and influenza infections both led to increased inpatient admissions. Our study prospectively assessed severe acute respiratory infections, their causative pathogens, and the resulting disease burden on German children's hospitals for the fall/winter 2023–2024 season.

Methods

From October 3, 2023 through April 16, 2024, children hospitalized with ARI as a primary diagnosis were monitored via a national survey established by the German Society for Pediatric Infectious Diseases (DGPI). Weekly data was collected on total hospital admissions, ARI-related admissions by pathogen (SARS-CoV-2, RSV, influenza, other), ICU admissions with ARI as a primary diagnosis, and respiratory support.

Results

Overall, 23% of German children's hospitals (77/334 centers) submitted 1234 survey reports. ARI-related hospital admissions surged starting in November 2023 and peaked in late December 2023 (53.4% of all admissions), in parallel with a peak in the average number of newly-admitted patients (aNA) with RSV (2.5 aNA). In comparison to the 2022/2023 season, fewer newborns and infants were admitted for ARI (4.7%, p < 0.001/1.9%, p = 0.05) and fewer required ICU treatment (5.3%, p = 0.02/5.6%, p = 0.001 respectively). In 74.9% of ICU patients, ventilation support was required—9.1% less than in the previous season.

Conclusion

The clinical burden on pediatric hospitals and ICUs is strongly influenced by the changing, annually circulating pathogens and affected age group. Therefore, a continuous, systematic, dynamic collection of ARI data is critical for assessing the ARI-related morbidity and the associated burden on health care systems.