First imported case of Candida auris infection in Milan, Italy: genomic characterisation

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2024年4月1日

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Sara Giordana Rimoldi,
Riccardo Nodari,
Alberto Rizzo,
Alessandro Tamoni,
Concetta Longobardi,
Cristina Pagani,
Silvia Grosso,
Federica Salari,
Laura Galimberti,
Pietro Olivieri,
Giuliano Rizzardini,
Emanuele Catena,
Spinello Antinori,
Francesco Comandatore,
Antonio Castelli,
Maria Rita Gismondo

摘要

Purpose

Candida auris, an emerging multidrug-resistant yeast, has been reported worldwide. In Italy, the first case was reported in 2019. We describe the first case of C. auris, imported from Greece, in Milan, using whole genome sequencing to characterise mutations associated with antifungal resistance.

Case presentation

On October 2022 an 80-year-old Italian man was hospitalised in Greece. In the absence of clinical improvement, the patient was transferred to our hospital, in Italy, where blood culture resulted positive for C. auris. Despite therapy, the patient died of septic shock. In a phylogenetic analysis the genome was assigned to Clade I with strains from Kenya, United Arab Emirates and India. D1/D2 region resulted identical to a Greek strain, as for many other strains from different World regions, highlighting the diffusion of this strain.

Conclusion

Importation of C. auris from abroad has been previously described. We report the first case of C. auris imported into Italy from Greece, according to phylogenetic analysis. This case reinforces the need for monitoring critically ill hospitalised patients also for fungi and addresses the need for the standardisation of susceptibility testing and strategies for diagnosis and therapy.