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<p><b>Background:</b> The microbiome is unique to each individual. It plays a key role in numerous physiological processes in the body. Intestinal dysbiosis is associated with various diseases.</p><p><b>Method:</b> This work provides an overview of the current state of knowledge regarding the role of microbiota in the lungs and the gut-lung axis.</p><p><b>Results and Conclusions:</b> Numerous studies have demonstrated a link between respiratory diseases and an altered lung microbiome. Dysbiosis of the gut microbiota influences the lung's immune response via gut-lung axis. Changes in the lung microbiome due to various environmental factors, such as smoking, particulate matter, or air pollution, contribute to lung cancer development. The composition of the gut microbiome influences the response to therapy with immune checkpoint inhibitors. Modulation of the gut microbiota through fecal microbiota transplantation (FMT), diet, prebiotics, probiotics, and synbiotics can positively influence the response to immunotherapy.</p>

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Darm-Lungen-Achse aus der gastroenterologischen Perspektive

  • 期刊论文

  • 发表日期：

    2025年12月9日

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  • Peter C. Konturek,
  • Talaat Ghopreal,
  • Walburga Dieterich,
  • Yurdagül Zopf

摘要

Background: The microbiome is unique to each individual. It plays a key role in numerous physiological processes in the body. Intestinal dysbiosis is associated with various diseases.

Method: This work provides an overview of the current state of knowledge regarding the role of microbiota in the lungs and the gut-lung axis.

Results and Conclusions: Numerous studies have demonstrated a link between respiratory diseases and an altered lung microbiome. Dysbiosis of the gut microbiota influences the lung's immune response via gut-lung axis. Changes in the lung microbiome due to various environmental factors, such as smoking, particulate matter, or air pollution, contribute to lung cancer development. The composition of the gut microbiome influences the response to therapy with immune checkpoint inhibitors. Modulation of the gut microbiota through fecal microbiota transplantation (FMT), diet, prebiotics, probiotics, and synbiotics can positively influence the response to immunotherapy.