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<p>Familial Hypercholesterolemia (FH), affecting 1 in 150-250 people, poses a significant cardiovascular risk. In the German Vroni Study, children aged 5-14 successfully screens for FH, combining LDL-C measurement with genetic testing. Early intervention reduces cardiovascular risks to general population levels. Over 28,000 children have been screened, identifying FH mutations in 1%. High acceptance rates among parents highlight feasibility. Vroni's approach, including reverse cascade screening for relatives, paves the way for integrating FH detection into routine care, advancing cardiovascular prevention.</p>

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Nie zu früh: Screening auf familiäre Hypercholesterinämie

  • 期刊论文

  • 发表日期：

    2025年3月21日

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  • Veronika Sanin,
  • Heribert Schunkert

摘要

Familial Hypercholesterolemia (FH), affecting 1 in 150-250 people, poses a significant cardiovascular risk. In the German Vroni Study, children aged 5-14 successfully screens for FH, combining LDL-C measurement with genetic testing. Early intervention reduces cardiovascular risks to general population levels. Over 28,000 children have been screened, identifying FH mutations in 1%. High acceptance rates among parents highlight feasibility. Vroni's approach, including reverse cascade screening for relatives, paves the way for integrating FH detection into routine care, advancing cardiovascular prevention.