Scholarlink

<p>Conventional cancer therapies face challenges such as toxicity, selectivity, and resistance. The green synthesis of silver nanoparticles (AgNPs) using plants provides a sustainable alternative by incorporating phytochemicals from Passiflora edulis into the particle corona. A review of physical, chemical, and green methods, focusing on P. edulis, aims to connect the extract composition with AgNP properties and bioactivity, while highlighting the verification needs before clinical use. This narrative review encompasses literature published up to 2025, sourced from PubMed, Scopus, Web of Science, and Google Scholar. It extracts synthesis conditions, physicochemical descriptors (size, shape, Zeta potential), and biological outcomes, with units harmonized for comparison across methods. Physical methods produce high-purity particles but are energy-intensive; chemical methods offer control over size and shape but depend on toxic reagents and require extensive purification; green methods using P. edulis operate under mild conditions and yield stable, spherical AgNPs (~ 10–50&#xa0;nm) capped with flavonoids and pectin, exhibiting a negative Zeta potential. In MCF-7 and SW480 cancer models, these AgNPs increase ROS levels, disrupt mitochondrial membrane potential, and induce apoptosis. However, direct in vivo evidence for efficacy, biodistribution, and safety is lacking. <i>P. edulis</i> enables the production of controllable, biocompatible AgNPs with promising anticancer activity, but current data are mainly in vitro, and mechanistic validation remains incomplete. Prospective animal studies followed by early-phase clinical trials are required to confirm efficacy, safety, and translatability.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Green synthesis of silver nanoparticles from Passiflora edulis: comparison with conventional methods and biomedical applications

  • 期刊论文

  • 发表日期：

    2025年12月10日

查看全文
  • F. Mutlag,
  • H. Elaibi,
  • E. Halvaci,
  • F. Sen

摘要

Conventional cancer therapies face challenges such as toxicity, selectivity, and resistance. The green synthesis of silver nanoparticles (AgNPs) using plants provides a sustainable alternative by incorporating phytochemicals from Passiflora edulis into the particle corona. A review of physical, chemical, and green methods, focusing on P. edulis, aims to connect the extract composition with AgNP properties and bioactivity, while highlighting the verification needs before clinical use. This narrative review encompasses literature published up to 2025, sourced from PubMed, Scopus, Web of Science, and Google Scholar. It extracts synthesis conditions, physicochemical descriptors (size, shape, Zeta potential), and biological outcomes, with units harmonized for comparison across methods. Physical methods produce high-purity particles but are energy-intensive; chemical methods offer control over size and shape but depend on toxic reagents and require extensive purification; green methods using P. edulis operate under mild conditions and yield stable, spherical AgNPs (~ 10–50 nm) capped with flavonoids and pectin, exhibiting a negative Zeta potential. In MCF-7 and SW480 cancer models, these AgNPs increase ROS levels, disrupt mitochondrial membrane potential, and induce apoptosis. However, direct in vivo evidence for efficacy, biodistribution, and safety is lacking. P. edulis enables the production of controllable, biocompatible AgNPs with promising anticancer activity, but current data are mainly in vitro, and mechanistic validation remains incomplete. Prospective animal studies followed by early-phase clinical trials are required to confirm efficacy, safety, and translatability.