<p>In this study, we evaluate the potential of a hybrid system that combines the synergy of catalytic ozonation and nanofiltration using functionalized titania ceramic membranes. The characteristics of pristine membranes were compared to their counterparts modified with a maghemite catalytic layer. The contribution of hydroxyl radicals was quantified using Desethyl-atrazine as a probe molecule, confirming that the Elovitz coefficient value increased from 2.3 × 10⁻⁹ (ozonation alone) to 2.4 × 10⁻⁸ with the γ-Fe₂O₃/TiO₂/α-Al₂O₃ membrane. Membrane surface charge characterization revealed dominant electrostatic repulsion effects at neutral pH, which played a critical role in the rejection of charged molecules. Mechanistic insights confirmed the generation of ·OH via redox cycling between Fe³⁺ and Fe²⁺, stabilized by the TiO₂ support, which maintained catalytic activity under neutral conditions. Multiple ozonation cycles revealed stable performance, highlighting the robustness and durability of the γ-Fe₂O₃/TiO₂/α-Al₂O₃ membrane. The hybrid system demonstrated enhanced removal of three model antibiotics, metronidazole, sulfamethoxazole, and amoxicillin, achieving near complete elimination of sulfamethoxazole and amoxicillin (&gt; 90%). Attractively, a threefold increase of amoxicillin abatement in the hybrid system has been observed compared to batch ozonation. This study aims to bridge the research gap and emphasize the importance of a comprehensive evaluation of functionalized tubular ceramic membranes in hybrid processes coupling nanofiltration with catalytic ozonation for advanced water treatment applications.</p>