<p>Ti₃C₂ MXene are two-dimensional nanomaterials that have attracted great attention for various applications nowadays. Due to their high specific surface area, good electrical conductivity, abundant oxygenated terminates, and ultra-thin 2D structure in confined regions, they could efficiently generate electron–hole pairs and transport them to the catalytically active sites on the surface, thus showing bright prospects in the field of photocatalysis. Recently, they have gradually been applied in the remediation of water pollution, either as catalyst or cocatalyst in the oxidation–reduction processes of pollutants. This review mainly focused on the latest developments in Ti₃C₂-based materials. Their synthesis method, modification technology, and photocatalytic performance toward various pollutants were summarized. These pollutants include antibiotics, dyes, phenolic substances, toxic ions (e.g., Cr₂O₇²⁻, UO₂²⁺, and BrO₃^–), pathogenic microorganisms, and antibiotic resistance genes. Moreover, their photocatalytic properties and mechanisms were also highlighted. Concluding remarks and prospects are also presented.</p> Graphical abstract <p></p>