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<p>Non-small cell lung cancer (NSCLC) remains a major therapeutic challenge due to drug resistance, limited treatment efficacy, and severe side effects. Although the natural flavonoid quercetin (Que) exhibits promising anticancer activity, its clinical application is restricted by poor aqueous solubility and low bioavailability. In this study, an electrochemically responsive hybrid composite, POSS-PAA-2@1@Que, was developed by integrating poly(acrylic acid) (PAA) with polyhedral oligomeric silsesquioxane (POSS), a natural product-derived functional molecule (compound 2, 2), and a π-conjugated electroactive molecule (compound 1, 1) for enhanced quercetin loading and controlled delivery. Structural characterization by FTIR confirmed the successful incorporation of different functional components, while SEM revealed a layered porous morphology beneficial for ion transport and molecular diffusion. Electrochemical investigations using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV) demonstrated that POSS-PAA-2@1@Que possessed enhanced electron-transfer capability, high sensitivity, and a concentration-dependent response toward Que detection, with a detection limit of 1 µM and excellent reproducibility. Furthermore, in vitro studies showed that the composite exhibited stronger inhibitory effects on the proliferation of NSCLC cells compared with free Que, indicating improved anticancer efficacy through enhanced drug delivery. These findings suggest that POSS-PAA-2@1@Que represents a multifunctional platform integrating electrochemical sensing capability with controlled quercetin delivery for potential applications in NSCLC therapy.</p>

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Silicon-based hybrid composite for enhanced electrochemical detection of quercetin and targeted inhibition of non-small cell lung cancer cell proliferation

  • 期刊论文

  • 发表日期：

    2026年8月3日

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  • Jie Sun,
  • Min Xue,
  • Jie Zhang

摘要

Non-small cell lung cancer (NSCLC) remains a major therapeutic challenge due to drug resistance, limited treatment efficacy, and severe side effects. Although the natural flavonoid quercetin (Que) exhibits promising anticancer activity, its clinical application is restricted by poor aqueous solubility and low bioavailability. In this study, an electrochemically responsive hybrid composite, POSS-PAA-2@1@Que, was developed by integrating poly(acrylic acid) (PAA) with polyhedral oligomeric silsesquioxane (POSS), a natural product-derived functional molecule (compound 2, 2), and a π-conjugated electroactive molecule (compound 1, 1) for enhanced quercetin loading and controlled delivery. Structural characterization by FTIR confirmed the successful incorporation of different functional components, while SEM revealed a layered porous morphology beneficial for ion transport and molecular diffusion. Electrochemical investigations using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV) demonstrated that POSS-PAA-2@1@Que possessed enhanced electron-transfer capability, high sensitivity, and a concentration-dependent response toward Que detection, with a detection limit of 1 µM and excellent reproducibility. Furthermore, in vitro studies showed that the composite exhibited stronger inhibitory effects on the proliferation of NSCLC cells compared with free Que, indicating improved anticancer efficacy through enhanced drug delivery. These findings suggest that POSS-PAA-2@1@Que represents a multifunctional platform integrating electrochemical sensing capability with controlled quercetin delivery for potential applications in NSCLC therapy.