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<p>Pyrrole scaffolds have an irreplaceable place in the category of organic heterocycles owing to their versatile profile. The development of pyrrole derivatives is highly demanding for the current scenario. In this context, green synthesis has attracted much more attention; however, it is challenging for the selection of green reaction conditions. For this purpose, Fe based NPs fulfil the green synthesis requirements under solvent-free reaction conditions. A solvent-free environment avoids the use of toxic organic solvents. The previous literature has witnessed the role of Fe based NPs-catalyzed solvent-free green synthesis of pyrrole analogues. This green methodology has notable advantages, such as high product yields, substrate scope compatibility, and short reaction times. The current review strongly focuses on the role of Fe based NPs towards the development of pyrrole derivatives under solvent-free conditions.</p> Graphical abstract <p></p>

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Iron based nanoparticles unlock solvent-free synthesis of pyrrole derivatives

  • 期刊论文

  • 发表日期：

    2026年7月24日

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  • Shubham Sharma,
  • Swati Rani,
  • Islom Kadirov,
  • Man Vir Singh,
  • Divya Avasthi,
  • Archana Dhyani,
  • Aaysha Pandey

摘要

Pyrrole scaffolds have an irreplaceable place in the category of organic heterocycles owing to their versatile profile. The development of pyrrole derivatives is highly demanding for the current scenario. In this context, green synthesis has attracted much more attention; however, it is challenging for the selection of green reaction conditions. For this purpose, Fe based NPs fulfil the green synthesis requirements under solvent-free reaction conditions. A solvent-free environment avoids the use of toxic organic solvents. The previous literature has witnessed the role of Fe based NPs-catalyzed solvent-free green synthesis of pyrrole analogues. This green methodology has notable advantages, such as high product yields, substrate scope compatibility, and short reaction times. The current review strongly focuses on the role of Fe based NPs towards the development of pyrrole derivatives under solvent-free conditions.

Graphical abstract