Scholarlink

<p>In this study, a cornuside-loaded multifunctional nanocomposite carrier (Fe₃O₄@CS-1@SiO₂@C) with magnetic, fluorescent, and microwave-responsive properties was designed and fabricated for controlled drug delivery. The structure and physicochemical properties of the composite were characterized by powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), nitrogen adsorption–desorption analysis, fluorescence spectroscopy, and magnetic measurements. The synthesized nanocomposite exhibited a branched mesoporous structure, a specific surface area of 262.75&#xa0;m² g⁻¹, and an average pore diameter of approximately 5.02&#xa0;nm. Magnetic measurements revealed a saturation magnetization of 36 emu g⁻¹, indicating favorable magnetic responsiveness. Drug release experiments showed that the composite displayed pH- and temperature-dependent release behavior, with cumulative release rates of 78.19 wt%, 61.04 wt%, and 56.80 wt% at pH 4, 5, and 7 after 360&#xa0;min, respectively, and 26.05 wt%, 56.67 wt%, and 64.56 wt% at 25&#xa0;°C, 37&#xa0;°C, and 50&#xa0;°C, respectively. In preliminary in vitro cell assays, cornuside-loaded nanoparticles (C-NP) alleviated palmitic acid (PA)-induced insulin resistance in HepG2 cells, as indicated by enhanced glycogen synthesis and reduced TNF-α secretion, and the suppression of gluconeogenic gene expression, exhibiting comparable therapeutic efficacy to the positive control Metformin. These findings suggest that Fe₃O₄@CS-1@SiO₂@C may serve as a promising multifunctional nanocarrier for controlled delivery of natural bioactive compounds, while further in vivo studies are required to evaluate its biodistribution, magnetic targeting capability, biosafety, and therapeutic efficacy.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Synthesis and characterization of cornuside-loaded Fe₃O₄/chitosan/silica nanocomposites for in vitro modulation of hepatocellular insulin resistance

  • 期刊论文

  • 发表日期：

    2026年7月6日

查看全文
  • Zhouni Xie,
  • Guili Liu,
  • Run Ge,
  • Qianqian Liao,
  • Zhuojun Li

摘要

In this study, a cornuside-loaded multifunctional nanocomposite carrier (Fe₃O₄@CS-1@SiO₂@C) with magnetic, fluorescent, and microwave-responsive properties was designed and fabricated for controlled drug delivery. The structure and physicochemical properties of the composite were characterized by powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), nitrogen adsorption–desorption analysis, fluorescence spectroscopy, and magnetic measurements. The synthesized nanocomposite exhibited a branched mesoporous structure, a specific surface area of 262.75 m² g⁻¹, and an average pore diameter of approximately 5.02 nm. Magnetic measurements revealed a saturation magnetization of 36 emu g⁻¹, indicating favorable magnetic responsiveness. Drug release experiments showed that the composite displayed pH- and temperature-dependent release behavior, with cumulative release rates of 78.19 wt%, 61.04 wt%, and 56.80 wt% at pH 4, 5, and 7 after 360 min, respectively, and 26.05 wt%, 56.67 wt%, and 64.56 wt% at 25 °C, 37 °C, and 50 °C, respectively. In preliminary in vitro cell assays, cornuside-loaded nanoparticles (C-NP) alleviated palmitic acid (PA)-induced insulin resistance in HepG2 cells, as indicated by enhanced glycogen synthesis and reduced TNF-α secretion, and the suppression of gluconeogenic gene expression, exhibiting comparable therapeutic efficacy to the positive control Metformin. These findings suggest that Fe₃O₄@CS-1@SiO₂@C may serve as a promising multifunctional nanocarrier for controlled delivery of natural bioactive compounds, while further in vivo studies are required to evaluate its biodistribution, magnetic targeting capability, biosafety, and therapeutic efficacy.