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<p>Synthesis of tetrazolo[1,5-a]pyridine derivatives using task-specific silica immobilized organosilane-based azide ionic liquid via the convenient multicomponent reaction is described. Treatment of di-(methyl and ethyl) acethylenedicarboxilate with arylaldehydes, malononitrile, and sodium azide at 80&#xa0;°C in the absence of any catalyst afforded to the expected products. Tetrazolo[1,5-a]pyridines were efficiently prepared in good to excellent yields under very simple and mild conditions. The significant advantages of this strategy include creating two C–N, two C–C bond and a N-N bond in one-pot procedure, operational simplicity, solvent and catalyst-free conditions. Simple handling of the azide containing nanoparticles and thus lowering the risks and hazards of a chemical process can offer other important advantages.</p>

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Efficient one-pot synthesis of multisubstituted tetrazolo[1,5-a]pyridines using task-specific silica immobilized organosilane-based azide ionic liquid

  • 期刊论文

  • 发表日期：

    2026年5月4日

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  • Hassan Valizadeh,
  • Mohammad Sadighpour Yam

摘要

Synthesis of tetrazolo[1,5-a]pyridine derivatives using task-specific silica immobilized organosilane-based azide ionic liquid via the convenient multicomponent reaction is described. Treatment of di-(methyl and ethyl) acethylenedicarboxilate with arylaldehydes, malononitrile, and sodium azide at 80 °C in the absence of any catalyst afforded to the expected products. Tetrazolo[1,5-a]pyridines were efficiently prepared in good to excellent yields under very simple and mild conditions. The significant advantages of this strategy include creating two C–N, two C–C bond and a N-N bond in one-pot procedure, operational simplicity, solvent and catalyst-free conditions. Simple handling of the azide containing nanoparticles and thus lowering the risks and hazards of a chemical process can offer other important advantages.