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<p>Natural enzymes play a crucial role in organic synthesis, biological processes, and pharmaceutical applications due to their high catalytic efficiency and compatibility with green chemistry principles. However, their practical use is often limited by complex synthesis and purification processes, difficulty in storage, and sensitivity to harsh environmental conditions. To address these challenges, artificial enzyme-like nanomaterials have attracted increasing attention as robust and cost-effective alternatives. In this study, a biomimetic catalytic system (Fe-GeHe) was developed by coating magnetic Fe₃O₄ nanoparticles with (3-trimethoxysilyl)propyl-ethylenediamine (TSPED), followed by functionalization with a gelatin–hematin complex to impart peroxidase-like activity. The structural and physicochemical properties of the synthesized catalyst were comprehensively characterized using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), vibrating-sample magnetometry (VSM), dynamic light scattering (DLS), and transmission electron microscopy (TEM), confirming the successful functionalization while preserving the crystalline structure and magnetic properties of the Fe₃O₄ core. The enzyme-mimicking oxidative activity of the Fe-GeHe catalyst was evaluated using rutin and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. The catalytic system demonstrated effective peroxidase-like activity in the presence of hydrogen peroxide. Notably, the Fe-GeHe nanocatalyst enabled the oxidative coupling of resveratrol to form resveratrol dimer, a bioactive compound known for its potent antioxidant properties and potential protective effects against cardiovascular diseases and certain cancers. The conversion of resveratrol monomers to the corresponding dimer increased progressively with reaction time, reaching a maximum conversion efficiency of 22% after 3&#xa0;h. These results highlight the potential of Fe-GeHe as a promising artificial enzyme platform for green catalytic synthesis of bioactive compounds.</p>

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Hematin-conjugated gelatin-g-iron oxide as a potential recoverable catalyst for oxidative dimerization of resveratrol

  • 期刊论文

  • 发表日期：

    2026年4月29日

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  • Phung Van Trung,
  • Van Du Cao,
  • Nguyen Ba Thao Nguyen,
  • Tan Phuoc Ton,
  • Pham Hong Ngoc,
  • Le Hang Dang,
  • Phuong Le Thi,
  • Ha Phuong Thu,
  • Dinh Trung Nguyen,
  • Ngoc Quyen Tran

摘要

Natural enzymes play a crucial role in organic synthesis, biological processes, and pharmaceutical applications due to their high catalytic efficiency and compatibility with green chemistry principles. However, their practical use is often limited by complex synthesis and purification processes, difficulty in storage, and sensitivity to harsh environmental conditions. To address these challenges, artificial enzyme-like nanomaterials have attracted increasing attention as robust and cost-effective alternatives. In this study, a biomimetic catalytic system (Fe-GeHe) was developed by coating magnetic Fe₃O₄ nanoparticles with (3-trimethoxysilyl)propyl-ethylenediamine (TSPED), followed by functionalization with a gelatin–hematin complex to impart peroxidase-like activity. The structural and physicochemical properties of the synthesized catalyst were comprehensively characterized using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), vibrating-sample magnetometry (VSM), dynamic light scattering (DLS), and transmission electron microscopy (TEM), confirming the successful functionalization while preserving the crystalline structure and magnetic properties of the Fe₃O₄ core. The enzyme-mimicking oxidative activity of the Fe-GeHe catalyst was evaluated using rutin and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. The catalytic system demonstrated effective peroxidase-like activity in the presence of hydrogen peroxide. Notably, the Fe-GeHe nanocatalyst enabled the oxidative coupling of resveratrol to form resveratrol dimer, a bioactive compound known for its potent antioxidant properties and potential protective effects against cardiovascular diseases and certain cancers. The conversion of resveratrol monomers to the corresponding dimer increased progressively with reaction time, reaching a maximum conversion efficiency of 22% after 3 h. These results highlight the potential of Fe-GeHe as a promising artificial enzyme platform for green catalytic synthesis of bioactive compounds.