<p>Degradation of 2, 4-Dichlorophenol (2, 4-DCP), a major endocrine-disrupting chemical, was carried out by sonication at 40&#xa0;kHz in the presence of CCl₄, H₂O₂, NaCl, Na₂SO₄, and ZnO nanoparticles. The decomposition of 2, 4- DCP was carried out at pH 2, 4.43, and 8 in the presence and absence of the additives above. The synthesized ZnO nanoparticle was characterized by UV and TEM. The concentration of the sonicated products was measured from the absorbance of a visible UV spectrophotometer. The degradation was also characterized by the FTIR. The experimental result showed that the degradation rate increased with the addition of additives. It was also found from the results that the increased sonication time and increased doses of additives favored the degradation. The synthesized ZnO nanoparticle improved the rate of decomposition of 2, 4-DCP. Maximum degradation of 2, 4-DCP was found in the presence of H₂O₂. The degradation followed the order of H₂O₂&gt; CCl₄&gt; ZnO&gt; Na₂SO₄&gt; NaCl. In addition, the degradation of 2, 4-DCP is also higher at pH 4.43 compared to the adjusted pH 2 and pH 8.</p>