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<p>The study’s objective was to assess the efficacy of the infrared (IR) spectrophotometric method for quantifying rutin in a given sample. The methodology involved generating IR spectra of rutin and utilising the C = O band at 1634.37 for the quantitative analysis by determining the area under the curve (AUC). This approach offers an alternative to analytical methods that require expensive, environmentally harmful organic solvents. The study also evaluated the method’s environmental impact and sustainability by using measures such as the Complex Green Analytical Procedure Index, the Analytical Greenness Calculator, and the red-green-blue algorithm tool. We developed an infrared (IR) spectroscopic method that employs a simple methanol-based sample preparation technique. Furthermore, the method exhibited a linear range of 5–30&#xa0;µg/mL, and statistical analysis showed a p-value of &lt; 0.001 at the 95% confidence level, indicating high reliability and accuracy. The evaluation was conducted in accordance with the Q2R1 ICH guideline, confirming that the method is suitable for routine quality control analysis without pre-extraction using green infrared (IR) spectroscopy. In conclusion, the study successfully demonstrated the capability of IR spectrophotometric techniques to accurately quantify rutin, which aligns with the principles of green-and-white analytical chemistry.</p>

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An insightful infrared spectroscopic analysis of rutin: the trajectory of method development and assessment for environmental sustainability using white and green analytical chemistry

  • 期刊论文

  • 发表日期：

    2026年3月12日

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  • Akramul Ansary,
  • Manoj Kashyap,
  • Amit kumar Das,
  • Piyong Sola,
  • Muslek Uddin Mazumder,
  • Koushik Nandan Dutta,
  • Biprojit Paul,
  • Manish Majumder

摘要

The study’s objective was to assess the efficacy of the infrared (IR) spectrophotometric method for quantifying rutin in a given sample. The methodology involved generating IR spectra of rutin and utilising the C = O band at 1634.37 for the quantitative analysis by determining the area under the curve (AUC). This approach offers an alternative to analytical methods that require expensive, environmentally harmful organic solvents. The study also evaluated the method’s environmental impact and sustainability by using measures such as the Complex Green Analytical Procedure Index, the Analytical Greenness Calculator, and the red-green-blue algorithm tool. We developed an infrared (IR) spectroscopic method that employs a simple methanol-based sample preparation technique. Furthermore, the method exhibited a linear range of 5–30 µg/mL, and statistical analysis showed a p-value of < 0.001 at the 95% confidence level, indicating high reliability and accuracy. The evaluation was conducted in accordance with the Q2R1 ICH guideline, confirming that the method is suitable for routine quality control analysis without pre-extraction using green infrared (IR) spectroscopy. In conclusion, the study successfully demonstrated the capability of IR spectrophotometric techniques to accurately quantify rutin, which aligns with the principles of green-and-white analytical chemistry.