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<p>The Henry reaction, also known as nitroaldol reaction is considered as a cornerstone in organic synthesis, renowned for its efficient C–C bond formation ability in complex molecules. Markedly, substantial developments in asymmetric Henry reaction have effectively expanded its applicability. Asymmetric Henry reaction, catalyzed via different metallic and non-metallic systems, generates enantiopure β-nitroalcohols. These enantiopure products act as pivotal chiral building blocks for the synthesis of a wide range of pharmaceuticals with potential biological applications and industrially important compounds. This review covers recent methodological developments in Henry reaction involving different catalytic systems including their mechanistic pathways.</p>

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Development of novel catalytic synthetic strategies for Henry reaction: a review

  • 期刊论文

  • 发表日期：

    2026年1月24日

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  • Muazzama Shehzadi,
  • Tanveer Hussain Bokhari,
  • Bushra Parveen,
  • Matloob Ahmad,
  • Syed Ali Raza Naqvi,
  • Asim Mansha,
  • Ameer Fawad Zahoor,
  • Freeha Hafeez,
  • Aijaz Rasool Chaudhry,
  • Ahmad Irfan

摘要

The Henry reaction, also known as nitroaldol reaction is considered as a cornerstone in organic synthesis, renowned for its efficient C–C bond formation ability in complex molecules. Markedly, substantial developments in asymmetric Henry reaction have effectively expanded its applicability. Asymmetric Henry reaction, catalyzed via different metallic and non-metallic systems, generates enantiopure β-nitroalcohols. These enantiopure products act as pivotal chiral building blocks for the synthesis of a wide range of pharmaceuticals with potential biological applications and industrially important compounds. This review covers recent methodological developments in Henry reaction involving different catalytic systems including their mechanistic pathways.