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<p>This study reports, for the first time, the synthesis and coordination behavior of a thiazolidine-4-one-5-acetic acid derivative bearing two long hydrocarbon chains, forming stable complexes with Cr(III), Ni(II), and Cu(II). The use of such a sterically demanding ligand, combined with isopropyl alcohol coordination, results in unique distorted octahedral geometries. These findings demonstrate that long-chain thiazolidine-4-one-5-acetic acid ligands can effectively coordinate with transition metal ions. Notably, the complexes display distinct and selective antimicrobial activities, with the Ni(II) complex showing promising antifungal efficacy against <i>C. albicans</i> and the Cu(II) complex exhibiting enhanced antibacterial activity against <i>S. aureus</i>. These findings highlight the potential of long-chain thiazolidine-based ligands in the design of biologically active metal complexes. Incorporating bulky hydrocarbon chains influences the coordination environment and enhances the biological activity of the resulting metal complexes. The selective antifungal and antibacterial properties observed in the Ni(II) and Cu(II) complexes, respectively, suggest that these ligands could be used to develop new metal-based antimicrobial agents. This study thus provides a basis for further exploration of long-chain thiazolidine derivatives in the fields of medicinal inorganic chemistry and drug design.</p> Graphical abstract <p></p>

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Synthesis and characterization of novel mononuclear nickel(II), copper(II) and chromium(III) complexes with N,N-dilaurylsubstituted thiazolidine-4-one-5-acetic acid

  • 期刊论文

  • 发表日期：

    2025年12月6日

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  • Mehmet Suat Aksoy,
  • Ayhan Yıldırım,
  • Aslı Göçenoğlu Sarıkaya

摘要

This study reports, for the first time, the synthesis and coordination behavior of a thiazolidine-4-one-5-acetic acid derivative bearing two long hydrocarbon chains, forming stable complexes with Cr(III), Ni(II), and Cu(II). The use of such a sterically demanding ligand, combined with isopropyl alcohol coordination, results in unique distorted octahedral geometries. These findings demonstrate that long-chain thiazolidine-4-one-5-acetic acid ligands can effectively coordinate with transition metal ions. Notably, the complexes display distinct and selective antimicrobial activities, with the Ni(II) complex showing promising antifungal efficacy against C. albicans and the Cu(II) complex exhibiting enhanced antibacterial activity against S. aureus. These findings highlight the potential of long-chain thiazolidine-based ligands in the design of biologically active metal complexes. Incorporating bulky hydrocarbon chains influences the coordination environment and enhances the biological activity of the resulting metal complexes. The selective antifungal and antibacterial properties observed in the Ni(II) and Cu(II) complexes, respectively, suggest that these ligands could be used to develop new metal-based antimicrobial agents. This study thus provides a basis for further exploration of long-chain thiazolidine derivatives in the fields of medicinal inorganic chemistry and drug design.

Graphical abstract