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<p>This study presents a green and efficient method for synthesizing tertiary alcohols of oxindole-indole hybrids in water from the reaction of isatin and indole derivatives. The reaction only requires 20&#xa0;mol% of NaHCO<sub>3</sub> as an additive. The process avoids the use of harmful solvents, and the products are isolated without using chromatographic techniques. Some of the compounds exhibited moderate antioxidant activity in DPPH assays. The activity was higher in compounds with electron-donating groups, which aid radical stabilization. The results highlight the value of structural modification and offer a sustainable approach for developing tertiary alcohols as an antioxidant.</p> Graphical abstract <p></p>

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Base-mediated Friedel-Crafts type reaction of Isatin and Indole in water to access tertiary alcohols and study of their antioxidant properties

  • 期刊论文

  • 发表日期：

    2025年12月6日

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  • Ariful Islam,
  • B. Shriya Saikia,
  • Mohit L. Deb,
  • Pranjal K. Baruah

摘要

This study presents a green and efficient method for synthesizing tertiary alcohols of oxindole-indole hybrids in water from the reaction of isatin and indole derivatives. The reaction only requires 20 mol% of NaHCO3 as an additive. The process avoids the use of harmful solvents, and the products are isolated without using chromatographic techniques. Some of the compounds exhibited moderate antioxidant activity in DPPH assays. The activity was higher in compounds with electron-donating groups, which aid radical stabilization. The results highlight the value of structural modification and offer a sustainable approach for developing tertiary alcohols as an antioxidant.

Graphical abstract