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<p>The current approach uses benzyl halides instead of benzaldehydes as key reagents because trimethylamine <i>N</i>-oxide is a safe and efficient oxidizing reagent to synthesize imidazo[1,2-<i>a</i>] pyrimidine analogues from different benzyl halides in one pot. Trimethylamine <i>N</i>-oxide generated in situ by the reaction of trimethylamine and hydrogen peroxide, catalyzes the three-component reaction with benzyl halide, 2-aminobenzimidazole/2-aminobenzthiazole, and phenyl acetylene to yield imidazo[1,2-<i>a</i>]pyrimidine analogues.</p> Graphical abstract <p></p>

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Trimethylamine N-oxide: An efficient reagent for the synthesis of functionalized fused imidazo[1,2-a]pyrimidines using benzyl halides

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • Narasashetty Jagadishbabu,
  • Kashifa Fazl-Ur-Rahman,
  • M. Sujatha,
  • Ankusab Noorahmadsab Nadaf

摘要

The current approach uses benzyl halides instead of benzaldehydes as key reagents because trimethylamine N-oxide is a safe and efficient oxidizing reagent to synthesize imidazo[1,2-a] pyrimidine analogues from different benzyl halides in one pot. Trimethylamine N-oxide generated in situ by the reaction of trimethylamine and hydrogen peroxide, catalyzes the three-component reaction with benzyl halide, 2-aminobenzimidazole/2-aminobenzthiazole, and phenyl acetylene to yield imidazo[1,2-a]pyrimidine analogues.

Graphical abstract