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<p>In this research, NiCo-MOF was first functionalized with ethylenediamine and then the obtained en/NiCo-MOF nanosheets were loaded with PdCl<sub>2</sub> and MnCl<sub>2</sub>. The structures of the resulting nanostructures (Pd@en/NiCo-MOF and Mn@en/NiCo-MOF) were characterized. The size of nanostructures was in the range 3–15 nm and exhibited powerful fluorescence emission bands. The optical band gaps of samples were determined by means of optical absorption spectra and were found to be in the range of 3.8–4.1 eV. The cytotoxic effect of nanostructures was tested against MCF-7 human breast cancer cells by MTT assay and based on the results their effectiveness follows the order of Pd@en/NiCo-MOF &gt; Mn@en/NiCo-MOF &gt; en/NiCo-MOF. The measured IC50 values ranged from 123.766 to 292.737. The expression of caspase 3, 8 and 9 genes in the treated cells of en/NiCo-MOF, Pd@ en/NiCo-MOF and Mn@en/NiCo-MOF was also investigated, and multifold increases compared to the control were observed in all cases.</p>

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Preparation of nickel–cobalt metal organic framework bearing palladium and manganese nanoparticles and investigation of their anticancer activity

  • 期刊论文

  • 发表日期：

    2025年8月13日

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  • Kaveh Parvanak Boroujeni,
  • Somayeh Reiisi,
  • Soudabeh Abdollahi

摘要

In this research, NiCo-MOF was first functionalized with ethylenediamine and then the obtained en/NiCo-MOF nanosheets were loaded with PdCl2 and MnCl2. The structures of the resulting nanostructures (Pd@en/NiCo-MOF and Mn@en/NiCo-MOF) were characterized. The size of nanostructures was in the range 3–15 nm and exhibited powerful fluorescence emission bands. The optical band gaps of samples were determined by means of optical absorption spectra and were found to be in the range of 3.8–4.1 eV. The cytotoxic effect of nanostructures was tested against MCF-7 human breast cancer cells by MTT assay and based on the results their effectiveness follows the order of Pd@en/NiCo-MOF > Mn@en/NiCo-MOF > en/NiCo-MOF. The measured IC50 values ranged from 123.766 to 292.737. The expression of caspase 3, 8 and 9 genes in the treated cells of en/NiCo-MOF, Pd@ en/NiCo-MOF and Mn@en/NiCo-MOF was also investigated, and multifold increases compared to the control were observed in all cases.