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<p>To develop the layered magadiite as the carrier of anticancer drugs, the intercalation and kinetic release of methotrexate (MTX) from cetyltrimethylammonium bromide (CTAB)-modified magadiite has been studied. X-ray diffraction (XRD) result showed that the basal spacing of magadiite varied from 1.54 to 2.87&#xa0;nm while the magadiite was modified with CTAB, and then the basal spacing was up to 3.55&#xa0;nm after the methotrexate was intercalated into the CTAB-modified magadiite. Zeta potential test revealed that the zeta potentials changed during the modification and intercalation. Compositional analyses suggested that loading capacity of the drug delivery system based magadiite for MTX was about 11.40%. In vitro drug release suggested that the drug release either in phosphate buffer solution (PBS, pH = 7.4) or in HCl solution (pH = 1.35) exhibited ExpDec3 mode. The releasing percentage of drugs was about 59.12% or 72.3% after drug release in PBS for 120&#xa0;h or in HCl solution for 700&#xa0;min, respectively. Moreover, the drug release exhibited good reproducible. These results indicate that the magadiite may be a promising carrier of MTX.</p>

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Intercalation and kinetic release of methotrexate from CTAB-modified magadiite

  • 期刊论文

  • 发表日期：

    2025年6月30日

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  • Yufeng Chen,
  • Fang Guo,
  • Yijun Liu,
  • Xiaoqiang Shang

摘要

To develop the layered magadiite as the carrier of anticancer drugs, the intercalation and kinetic release of methotrexate (MTX) from cetyltrimethylammonium bromide (CTAB)-modified magadiite has been studied. X-ray diffraction (XRD) result showed that the basal spacing of magadiite varied from 1.54 to 2.87 nm while the magadiite was modified with CTAB, and then the basal spacing was up to 3.55 nm after the methotrexate was intercalated into the CTAB-modified magadiite. Zeta potential test revealed that the zeta potentials changed during the modification and intercalation. Compositional analyses suggested that loading capacity of the drug delivery system based magadiite for MTX was about 11.40%. In vitro drug release suggested that the drug release either in phosphate buffer solution (PBS, pH = 7.4) or in HCl solution (pH = 1.35) exhibited ExpDec3 mode. The releasing percentage of drugs was about 59.12% or 72.3% after drug release in PBS for 120 h or in HCl solution for 700 min, respectively. Moreover, the drug release exhibited good reproducible. These results indicate that the magadiite may be a promising carrier of MTX.