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<p>Due to their diverse spectrum of biological properties, compounds containing thymol or 1,2,3-triazole have attracted a lot of attention in the disciplines of organic synthesis, pharmaceutical and medicinal sciences. Here, a "click" chemistry was used to generate a series of heterocyclic compounds combining thymol and 1,2,3-triazole compounds <b>4–11</b> through the cycloaddition reaction of alkyne thymol <b>3</b> with aromatic azide, which was catalyzed by copper. Additionally, all manufactured items' insecticidal qualities were tested on <i>Aphis gossypii</i> nymphs and adults. Conversely, it is suggested that neonicotinoid chemicals are the most effective pesticides against aphids and a variety of other pests. Numerous pesticide chemicals are found to be new. Consequently, several thymol derivatives were chemically produced to function as neonicotinoids' counterparts, a large family of insecticides. The target compound <b>7</b> has the highest insecticidal bioactivity, with an LC<sub>50</sub> value of 1.97&#xa0;mg/L. Notably, compounds <b>5</b>–<b>7</b> demonstrated excellent inhibition against <i>Bacillus cereus</i> and <i>Escherichia coli</i> more than standard antibacterial drugs (ciprofloxacin) at concentration (<b>A</b> = 1000, <b>B</b> = 3.000, <b>C</b> = 5000&#xa0;ppm). This study makes the case for eliminating any compounds that might be employed in the future as antibiotics or insecticidal agents. </p>

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Functionalized triazole: synthesis and chemical characterization of 1-aryl-4-thymolyl-1H-1,2,3-triazole derivatives as antibacterial and insecticidal agents

  • 期刊论文

  • 发表日期：

    2025年6月12日

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  • Mohamed A. Gad,
  • Hany M. Abd El-Lateef,
  • Mai M. Khalaf,
  • Mohamed Gouda,
  • Hemdan El-Shamy,
  • Tamer Mohamed Abdelghani Ibrahim,
  • Mohammad Mahboob Alam,
  • Amer A. Amer,
  • Saleh AL-Ghamdi,
  • Antar A. Abdelhamid

摘要

Due to their diverse spectrum of biological properties, compounds containing thymol or 1,2,3-triazole have attracted a lot of attention in the disciplines of organic synthesis, pharmaceutical and medicinal sciences. Here, a "click" chemistry was used to generate a series of heterocyclic compounds combining thymol and 1,2,3-triazole compounds 4–11 through the cycloaddition reaction of alkyne thymol 3 with aromatic azide, which was catalyzed by copper. Additionally, all manufactured items' insecticidal qualities were tested on Aphis gossypii nymphs and adults. Conversely, it is suggested that neonicotinoid chemicals are the most effective pesticides against aphids and a variety of other pests. Numerous pesticide chemicals are found to be new. Consequently, several thymol derivatives were chemically produced to function as neonicotinoids' counterparts, a large family of insecticides. The target compound 7 has the highest insecticidal bioactivity, with an LC50 value of 1.97 mg/L. Notably, compounds 5–7 demonstrated excellent inhibition against Bacillus cereus and Escherichia coli more than standard antibacterial drugs (ciprofloxacin) at concentration (A = 1000, B = 3.000, C = 5000 ppm). This study makes the case for eliminating any compounds that might be employed in the future as antibiotics or insecticidal agents.