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<p>This study investigated the electrochemical oxidation of methyldopa at the surface of the glassy carbon electrode (GCE) modified with copper-complexed metal nanoparticles. A bimetallic Cu(II) complex, [Cu2(L)].3H2O, was synthesized from the macrocyclic Schiff base ligand L: 2,7,13,18-tetramethyl-3,6,14,17-tetraazatricyclo-[17.3.1.1]-tetracosa-1(23), 2, 6, 8(24), 9, 11, 13, 17, 19, 21-decaene-9, 11, 20, 22-tetraol. This nanostructure, sized approximately 32 ± 0.5&#xa0;nm, was produced using a fast, low-cost, and safe sonochemical method. 3H<sub>2</sub>O Schiff base complex nanoparticles (Cu<sub>2</sub>(L)N), Fourier transform infrared, X-ray diffraction, field emission scanning electron microscope, and transmission electron microscopy analysis were recorded. In this work, cyclic voltammetry, differential pulse voltammetry, and potential linear scanning voltammetry were used. Combining these methods with excellent electrocatalytic properties of copper-complexed nanoparticles enables the drug to be measured in small quantities. The peak potential was recorded for methyldopa in phosphate buffer solution at pH = 7300&#xa0;mV relative to Ag/AgCl/KCl. Under optimal conditions, the oxidation of methyldopa at pH 7 occurs at a potential of approximately 347&#xa0;mV, which is more negative than that of the unmodified GCE. A linear amplitude curve was obtained in the 0.5–90&#xa0;μM concentration range, with a detection limit of 0.15&#xa0;μM.</p>

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Facile sonochemical synthesis of binuclear copper Schiff base complexed nanoparticles for electrochemical detection of methyldopa

  • 期刊论文

  • 发表日期：

    2025年5月17日

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  • Saleh Javaherian,
  • Elaheh Molaakbari,
  • Tayabeh Shamspur,
  • Zeinab Tohidiyan,
  • Ali Mostafavi

摘要

This study investigated the electrochemical oxidation of methyldopa at the surface of the glassy carbon electrode (GCE) modified with copper-complexed metal nanoparticles. A bimetallic Cu(II) complex, [Cu2(L)].3H2O, was synthesized from the macrocyclic Schiff base ligand L: 2,7,13,18-tetramethyl-3,6,14,17-tetraazatricyclo-[17.3.1.1]-tetracosa-1(23), 2, 6, 8(24), 9, 11, 13, 17, 19, 21-decaene-9, 11, 20, 22-tetraol. This nanostructure, sized approximately 32 ± 0.5 nm, was produced using a fast, low-cost, and safe sonochemical method. 3H2O Schiff base complex nanoparticles (Cu2(L)N), Fourier transform infrared, X-ray diffraction, field emission scanning electron microscope, and transmission electron microscopy analysis were recorded. In this work, cyclic voltammetry, differential pulse voltammetry, and potential linear scanning voltammetry were used. Combining these methods with excellent electrocatalytic properties of copper-complexed nanoparticles enables the drug to be measured in small quantities. The peak potential was recorded for methyldopa in phosphate buffer solution at pH = 7300 mV relative to Ag/AgCl/KCl. Under optimal conditions, the oxidation of methyldopa at pH 7 occurs at a potential of approximately 347 mV, which is more negative than that of the unmodified GCE. A linear amplitude curve was obtained in the 0.5–90 μM concentration range, with a detection limit of 0.15 μM.