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<p>The synthesis of a Schiff base ligand 5-(((7-chlorobenzo[d]thiazol-2-yl)imino)methyl)-2-methoxyphenol (L) derived from the condensation of 5-amino-1,3,4-thiadaizole 2- thiol and 3-hydroxy-4-methoxy benzaldehyde and its Cu(II), Co(II), Mn(II), Ni(II), and Zn(II) metal complexes in 2:1 stoichiometric ratio (2HL:M). The formation of the ligand and its metal complexes were evaluated using MS technique, FTIR, UV–visible, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, and thermogravimetric analysis. Molecular docking studies were conducted using AutoDock 4.2 to predict the binding affinity and interaction of L and its metal complexes with potential biological targets. The larvicidal activity of L and its metal complexes was evaluated by exposing larvae to various concentrations of the compounds. The mortality rates of the larvae were determined after 24&#xa0;h of exposure. The Cu(II) complex exhibited the most effective larvicidal activity, with a mortality rate of 66%. The survival rate of the larvae exposed to the Cu(II) complex was only 34%, indicating its high toxicity. The free Schiff base ligand showed moderate larvicidal activity with a mortality rate of approximately 50%, meaning roughly half of the larvae survived. This suggests that while L is somewhat effective, its larvicidal activity is significantly enhanced upon metal coordination, especially with Cu(II). </p>

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Synthesis, spectral characterization, molecular docking studies, and larvicidal activity of some transition metal complexes with Schiff base ligand

  • 期刊论文

  • 发表日期：

    2025年7月16日

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  • Deepika Puttaveerappa,
  • Vinusha Honnalagere Marisamy,
  • Muneera Begum,
  • Rekha Nanjappagowda Dharmappa,
  • P. Akhileshwari

摘要

The synthesis of a Schiff base ligand 5-(((7-chlorobenzo[d]thiazol-2-yl)imino)methyl)-2-methoxyphenol (L) derived from the condensation of 5-amino-1,3,4-thiadaizole 2- thiol and 3-hydroxy-4-methoxy benzaldehyde and its Cu(II), Co(II), Mn(II), Ni(II), and Zn(II) metal complexes in 2:1 stoichiometric ratio (2HL:M). The formation of the ligand and its metal complexes were evaluated using MS technique, FTIR, UV–visible, 1H-NMR, 13C-NMR, and thermogravimetric analysis. Molecular docking studies were conducted using AutoDock 4.2 to predict the binding affinity and interaction of L and its metal complexes with potential biological targets. The larvicidal activity of L and its metal complexes was evaluated by exposing larvae to various concentrations of the compounds. The mortality rates of the larvae were determined after 24 h of exposure. The Cu(II) complex exhibited the most effective larvicidal activity, with a mortality rate of 66%. The survival rate of the larvae exposed to the Cu(II) complex was only 34%, indicating its high toxicity. The free Schiff base ligand showed moderate larvicidal activity with a mortality rate of approximately 50%, meaning roughly half of the larvae survived. This suggests that while L is somewhat effective, its larvicidal activity is significantly enhanced upon metal coordination, especially with Cu(II).