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<p>The polycyclic <i>N</i>-heterocycles show several fascinating biological activities. Developing of new procedures for preparing of these compounds is an attractive and challenging field. A new series of 6<i>H</i>-indeno[2,1-<i>e</i>]pyrazolo[1,5-<i>a</i>]pyrimidin-6-one scaffolds were prepared through the reaction between 5-amino-pyrazoles, and ninhydrin 2-oxo-2-phenylethane thiolate derivatives. Some advantages of this green, regioselective, and sonicated protocol include available starting materials, simple operation, short reaction time, and easy workup and purification. This method also enjoys excellent tolerance toward various substituents. </p> Graphical abstract <p> A new series of 6<i>H</i>-indeno[2,1-<i>e</i>]pyrazolo[1,5-<i>a</i>]pyrimidin-6-one scaffolds were prepared through an efficient, regioselective, and green procedure. This procedure included the reaction between ninhydrin 2-oxo-2-phenylethane thiolate derivatives, methyl iodide, and 5-amino-pyrazoles in ethanol under ultrasonication. Some other unique advantages of this method are excellent tolerance to various substituents, accessible precursors, simple operation, and easy workup and purification.</p>

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Green procedure for regioselective synthesis of 6H-indeno[2,1-e]pyrazolo[1,5-a]pyrimidin-6-one scaffolds under sonication condition

  • 期刊论文

  • 发表日期：

    2025年5月4日

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  • Abdolali Alizadeh,
  • Ebrahim Amir Chelebari,
  • Reza Rezaiyehraad

摘要

The polycyclic N-heterocycles show several fascinating biological activities. Developing of new procedures for preparing of these compounds is an attractive and challenging field. A new series of 6H-indeno[2,1-e]pyrazolo[1,5-a]pyrimidin-6-one scaffolds were prepared through the reaction between 5-amino-pyrazoles, and ninhydrin 2-oxo-2-phenylethane thiolate derivatives. Some advantages of this green, regioselective, and sonicated protocol include available starting materials, simple operation, short reaction time, and easy workup and purification. This method also enjoys excellent tolerance toward various substituents.

Graphical abstract

A new series of 6H-indeno[2,1-e]pyrazolo[1,5-a]pyrimidin-6-one scaffolds were prepared through an efficient, regioselective, and green procedure. This procedure included the reaction between ninhydrin 2-oxo-2-phenylethane thiolate derivatives, methyl iodide, and 5-amino-pyrazoles in ethanol under ultrasonication. Some other unique advantages of this method are excellent tolerance to various substituents, accessible precursors, simple operation, and easy workup and purification.