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<p>A series of (<i>E</i>)-3-((2-methoxynaphthalen-1-yl)methylene)-1-((1-phenyl-1<i>H</i>-1,2,3-triazol-4-yl)methyl)indolin-2-ones (7(a–l)) compounds were synthesized by using available starting materials such as (<i>E</i>)-3-((2-methoxynaphthalen-1-yl)methylene)indolin-2-one (4), which in-turn leads to the formation of active propargyl precursor and finally undergoes click reaction (active alkyne and different aryl azides) to get compound formula 7(a–l). Further, the synthesized compounds 7(a–l) were studied for in-vitro antimicrobial screening against Gram-positive <i>Staphylococcus aureus</i> and Gram-negative <i>Pseudomonas aeruginosa</i> bacterial strains, as well as <i>Fusarium oxysporum</i> and <i>Aspergillus niger</i> as fungal strains by agar disc diffusion method. From in-vitro antimicrobial investigation, it was revealed that among all the synthesized compounds, 7c, 7b, 7e, 7&#xa0;g, and 7&#xa0;h showed promising antibacterial activity and comparable with the standard drugs.</p>

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Synthesis, and antimicrobial activity of some novel 1, 2, 3-triazol-4-yl conjugated indolin-2-one derivatives

  • 期刊论文

  • 发表日期：

    2025年3月26日

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  • S. Shahjahan,
  • Narjis Fatima,
  • Md. Farveen,
  • Ayub Shaik,
  • Dasari Ayodhya,
  • Ahmed Kamal

摘要

A series of (E)-3-((2-methoxynaphthalen-1-yl)methylene)-1-((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)indolin-2-ones (7(a–l)) compounds were synthesized by using available starting materials such as (E)-3-((2-methoxynaphthalen-1-yl)methylene)indolin-2-one (4), which in-turn leads to the formation of active propargyl precursor and finally undergoes click reaction (active alkyne and different aryl azides) to get compound formula 7(a–l). Further, the synthesized compounds 7(a–l) were studied for in-vitro antimicrobial screening against Gram-positive Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa bacterial strains, as well as Fusarium oxysporum and Aspergillus niger as fungal strains by agar disc diffusion method. From in-vitro antimicrobial investigation, it was revealed that among all the synthesized compounds, 7c, 7b, 7e, 7 g, and 7 h showed promising antibacterial activity and comparable with the standard drugs.