Synthesis and antimicrobial evaluation of some novel heterocyclic compounds based on azo chromene moiety

Developing new agents for treating bacterial and fungal resistance remain a top priority in developing countries because the antibiotic resistance is one of the major threats to human health. Thus, the current work was designed to synthesize a new series of chromene and pyrazole derivatives based on 2-hydroxy-5-((4-nitrophenyl) diazenyl) benzaldehyde moiety. The structure of the designed derivatives was confirmed using different spectroscopic techniques (FT-IR and NMR) and elemental analysis. Most of the designed derivatives were evaluated against six standard microbial strains. Compounds 3, 12, 13 and 16 showed excellent antimicrobial activity against S. faecalis with MIC (3.91) µg/ml closed to Penicillin G and MBC values (15.6, 31.3) µg/ml. In addition, chromene 14 exhibited an inhibition effect better than the positive control Penicillin G with MIC (1.95) µg/ml and MBC value (31.3) µg/ml.