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<p>Bleeding is one of the main causes of death in the world, accounting for about 30% of deaths. Blood clotting substances, especially natural substances, play an important role in reducing this mortality. In addition to shortening blood clotting time, these substances should have characteristics such as biocompatibility, biodegradability, and low cost. In this research, an optimal combination of oxidized cellulose, gelatin, and sodium alginate has been investigated as a hemostatic powder. Oxidized regenerated cellulose (ORC) was used in this study due to its coagulating properties and low toxicity. Additionally, zinc oxide has been used as an antibacterial agent in this composition. The oxidation degree of oxidized regenerated cellulose was calculated to be 22%. In this research, Design Expert software was used to determine the optimal composition and gelation time. The variables of this experiment were the sodium alginate/gelatin composite, oxidized regenerated cellulose, and zinc oxide. The results showed that by increasing the amount of sodium alginate, the gelation time decreased, and also by increasing zinc oxide, the number of bacterial colonies decreased. Studies show that increasing the amount of sodium alginate increases the properties of the gel. The results show that the combination of 75% sodium alginate, 23% gelatin, 1% ORC, and 1% ZnO has the best performance in creating a stable and effective gel for controlling deep and superficial wound bleeding.</p> Graphical Abstract <p></p>

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Optimization of oxidized regenerated cellulose/gelatin/sodium alginate/zinc oxide gel-forming powder composite for wound management applications with a focus on gelation time and antibacterial activity

  • 期刊论文

  • 发表日期：

    2026年2月23日

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  • Amir Eslahi Kalurazi,
  • Mohsen Shahrousvand,
  • Seyed Mohammad Davachi,
  • Jamshid Mohammadi-Rovshandeh,
  • Mohammadreza Mobayen

摘要

Bleeding is one of the main causes of death in the world, accounting for about 30% of deaths. Blood clotting substances, especially natural substances, play an important role in reducing this mortality. In addition to shortening blood clotting time, these substances should have characteristics such as biocompatibility, biodegradability, and low cost. In this research, an optimal combination of oxidized cellulose, gelatin, and sodium alginate has been investigated as a hemostatic powder. Oxidized regenerated cellulose (ORC) was used in this study due to its coagulating properties and low toxicity. Additionally, zinc oxide has been used as an antibacterial agent in this composition. The oxidation degree of oxidized regenerated cellulose was calculated to be 22%. In this research, Design Expert software was used to determine the optimal composition and gelation time. The variables of this experiment were the sodium alginate/gelatin composite, oxidized regenerated cellulose, and zinc oxide. The results showed that by increasing the amount of sodium alginate, the gelation time decreased, and also by increasing zinc oxide, the number of bacterial colonies decreased. Studies show that increasing the amount of sodium alginate increases the properties of the gel. The results show that the combination of 75% sodium alginate, 23% gelatin, 1% ORC, and 1% ZnO has the best performance in creating a stable and effective gel for controlling deep and superficial wound bleeding.

Graphical Abstract