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<p>Poly(glycerol sebacate) (PGS) is a biodegradable polymer extensively utilized in tissue engineering due to its advantageous mechanical properties, biocompatibility, and controllable degradation rates. This study focuses on the fabrication of PGS scaffolds treated with eugenol plasma to introduce antibacterial properties and enhance cellular proliferation. The PGS scaffolds were created using a salt leaching technique and subsequently modified through surface treatment with eugenol plasma at various power levels, specifically 30, 60, and 120&#xa0;W. The physicochemical properties of the scaffolds were characterized using advanced techniques such as field emission scanning electron microscopy (FE-SEM), energy-dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). The results indicated that plasma treatment significantly modified the scaffold's surface morphology, leading to increased hydrophobicity and alterations in the chemical composition, particularly with the incorporation of nitrogen and oxygen species. Biological assays confirmed that the modified scaffolds maintained biocompatibility with human gingival fibroblasts, demonstrating their potential for use in tissue engineering. Additionally, antibacterial tests revealed significant inhibition of <i>Staphylococcus aureus</i> at lower plasma powers (30&#xa0;W), suggesting that eugenol plasma treatment effectively enhances both the antibacterial and surface properties of PGS scaffolds. These findings indicate the suitability of these modified scaffolds for applications in tissue engineering and infection control, highlighting their potential in advancing biomedical applications.</p> Graphical abstract <p></p>

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Surface modification of poly(glycerol sebacate) scaffolds with eugenol plasma to incorporate antibacterial properties

  • 期刊论文

  • 发表日期：

    2025年10月21日

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  • Julio César Sánchez-Pech,
  • Cristian Carrera-Figueiras,
  • Gaspar Eduardo Martín-Pat,
  • Antonio David Abreu Rejón,
  • Ángel Bacelis-Jiménez,
  • Eduardo Gutiérrez-Alcántara,
  • Nayeli Rodríguez-Fuentes,
  • Víctor Rejón,
  • Alejandro Ávila-Ortega

摘要

Poly(glycerol sebacate) (PGS) is a biodegradable polymer extensively utilized in tissue engineering due to its advantageous mechanical properties, biocompatibility, and controllable degradation rates. This study focuses on the fabrication of PGS scaffolds treated with eugenol plasma to introduce antibacterial properties and enhance cellular proliferation. The PGS scaffolds were created using a salt leaching technique and subsequently modified through surface treatment with eugenol plasma at various power levels, specifically 30, 60, and 120 W. The physicochemical properties of the scaffolds were characterized using advanced techniques such as field emission scanning electron microscopy (FE-SEM), energy-dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). The results indicated that plasma treatment significantly modified the scaffold's surface morphology, leading to increased hydrophobicity and alterations in the chemical composition, particularly with the incorporation of nitrogen and oxygen species. Biological assays confirmed that the modified scaffolds maintained biocompatibility with human gingival fibroblasts, demonstrating their potential for use in tissue engineering. Additionally, antibacterial tests revealed significant inhibition of Staphylococcus aureus at lower plasma powers (30 W), suggesting that eugenol plasma treatment effectively enhances both the antibacterial and surface properties of PGS scaffolds. These findings indicate the suitability of these modified scaffolds for applications in tissue engineering and infection control, highlighting their potential in advancing biomedical applications.

Graphical abstract