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<p>The development of anti-tumor drugs can benefit greatly from the use of natural drugs, which are compounds derived from plants, marine organisms, and micro-organisms. The active ingredients in these drugs function by blocking proliferation and controlling signaling pathways, among other mechanisms. After the large conjugated structure system of curcumin–BF<sub>2</sub> and cyanine fluorescence-labeled IR-813 undergoing π–π superposition, it hydrogenated soybean phospholipids which encapsulated the CIRP in water-in-oil form. Their fluorescence stability is good in tetrahydrofuran (THF) and dichloromethane (DCM). The particle had a zeta potential of 60.2&#xa0;mV and a size of approximately 111.6 ± 57.49&#xa0;nm. Consistent with the findings of transmission electron microscopy (TEM), these results demonstrate the nanoparticles' good stability and dispersion. The fluorescent complex is securely enclosed within the diliposomes, which explains the above quality. The release curve of CIRP in the gastrointestinal environment experienced significant changes at pH values of 5, 6, and 7, particularly at those pH values, which indicated an upward trend. It was discovered in tumor inhibition studies that the CIRP concentration reached 60&#xa0;µg/mL, and the cell inhibition rate of HCT-116 reached 74.2%. This implies that CIRP is toxic to HCT-116 cells and has a high proliferative capacity; therefore, targeting and biocompatibility in cell imaging are closely linked to good bioactivity. Such a one-pot method design is not only efficient and simple, but also practical, providing new ideas for the visual nano-preparation of insoluble natural drugs in the future.</p> Graphical Abstract <p></p>

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Preparation, sustained-release and bioactivity of curcumin–BF2/IR-813 cyanine-strategy nanofluorescent complex encapsulated by hydrogenated soybean phospholipids

  • 期刊论文

  • 发表日期：

    2025年11月8日

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  • Xiujie Duan,
  • Jiang Zhenhua,
  • Feng Jin

摘要

The development of anti-tumor drugs can benefit greatly from the use of natural drugs, which are compounds derived from plants, marine organisms, and micro-organisms. The active ingredients in these drugs function by blocking proliferation and controlling signaling pathways, among other mechanisms. After the large conjugated structure system of curcumin–BF2 and cyanine fluorescence-labeled IR-813 undergoing π–π superposition, it hydrogenated soybean phospholipids which encapsulated the CIRP in water-in-oil form. Their fluorescence stability is good in tetrahydrofuran (THF) and dichloromethane (DCM). The particle had a zeta potential of 60.2 mV and a size of approximately 111.6 ± 57.49 nm. Consistent with the findings of transmission electron microscopy (TEM), these results demonstrate the nanoparticles' good stability and dispersion. The fluorescent complex is securely enclosed within the diliposomes, which explains the above quality. The release curve of CIRP in the gastrointestinal environment experienced significant changes at pH values of 5, 6, and 7, particularly at those pH values, which indicated an upward trend. It was discovered in tumor inhibition studies that the CIRP concentration reached 60 µg/mL, and the cell inhibition rate of HCT-116 reached 74.2%. This implies that CIRP is toxic to HCT-116 cells and has a high proliferative capacity; therefore, targeting and biocompatibility in cell imaging are closely linked to good bioactivity. Such a one-pot method design is not only efficient and simple, but also practical, providing new ideas for the visual nano-preparation of insoluble natural drugs in the future.

Graphical Abstract