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<p>This study develops and evaluates noscapine (NSP)-loaded bovine serum albumin (BSA) nanoparticles (BSA-NPs) based on natural biodegradable polymers to examine their potential application in food and pharmaceutical industry. The process of formulation was optimized to improve the stability, entrapment efficacy (EE), and the controlled release of NSP. Various physicochemical characteristics of the BSA-NPs were examined by a sophisticated analysis method, such as differential scanning calorimetry (DSC) for thermal analysis, Fourier transform infrared spectrophotometry (FTIR) for chemical analysis and scanning electron microscopy (SEM) for morphological analysis. Moreover, important parameters such as EE, particle size (PS), drug loading (DL), and in vitro release profiles were systematically examined. Among various formulations, nanoparticles coated with natural biodegradable polymer poly-<i>L</i>-lysine provided the highest activity. The ideal PS ranged from 204.31 ± 7.5 to 281.72 ± 13.4&#xa0;nm and the ZP ranging from −&#xa0;10.2 ± 1.4 to + 27.01 ± 2.41&#xa0;mV had satisfactory colloidal stability. EE was determined as 39.23% ± 1.2% and 41.35% ± 1.3%, which provides DL efficiently. In addition, lyophilized poly<i>-L</i>-lysine-coated BSA-NPs were established to be stable for 90&#xa0;days at varying storage conditions. Successful encapsulation of NSP-loaded BSA-NPs exhibits novel gateways for targeted drug delivery systems that ensure prolonged therapeutic action with minimized side effects.</p> Graphical abstract <p></p>

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Noscapine-loaded bovine serum albumin nanoparticles: formulation and physicochemical characterization

  • 期刊论文

  • 发表日期：

    2025年8月13日

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  • Durgaramani Sivadasan,
  • Yosif Almoshari,
  • Krishnaraju Venkatesan,
  • Fazil Ahmad,
  • Jamal Moideen Muthu Mohamed

摘要

This study develops and evaluates noscapine (NSP)-loaded bovine serum albumin (BSA) nanoparticles (BSA-NPs) based on natural biodegradable polymers to examine their potential application in food and pharmaceutical industry. The process of formulation was optimized to improve the stability, entrapment efficacy (EE), and the controlled release of NSP. Various physicochemical characteristics of the BSA-NPs were examined by a sophisticated analysis method, such as differential scanning calorimetry (DSC) for thermal analysis, Fourier transform infrared spectrophotometry (FTIR) for chemical analysis and scanning electron microscopy (SEM) for morphological analysis. Moreover, important parameters such as EE, particle size (PS), drug loading (DL), and in vitro release profiles were systematically examined. Among various formulations, nanoparticles coated with natural biodegradable polymer poly-L-lysine provided the highest activity. The ideal PS ranged from 204.31 ± 7.5 to 281.72 ± 13.4 nm and the ZP ranging from − 10.2 ± 1.4 to + 27.01 ± 2.41 mV had satisfactory colloidal stability. EE was determined as 39.23% ± 1.2% and 41.35% ± 1.3%, which provides DL efficiently. In addition, lyophilized poly-L-lysine-coated BSA-NPs were established to be stable for 90 days at varying storage conditions. Successful encapsulation of NSP-loaded BSA-NPs exhibits novel gateways for targeted drug delivery systems that ensure prolonged therapeutic action with minimized side effects.

Graphical abstract