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<p>We investigated the enhancement of the mechanical and functional properties of polyethylene glycol (PEG)-based nanofiber membranes for wound dressing applications. By incorporating hydroxypropyl cellulose (HPC) and using ethanol as the solvent, we improved the stress–strain performance of PEG/HPC nanofiber membranes by over 30% compared to pure PEG membranes. This modification effectively addresses the issue of insufficient extensibility in PEG-based membranes, a critical factor for their use in wound care. Furthermore, to overcome the challenge of rapid drug release, we introduced urushiol (UR), a natural compound extracted from lacquer trees, as both a sustained-release and antibacterial agent. This addition enhances the release profile and provides antibacterial properties. Furthermore, the incorporation of &#xa0;1&#xa0;wt% nano-zinc oxide significantly boosted the antibacterial efficacy, achieving over 95% inhibition. For greater material versatility, double conjugate electrospinning was employed to coat the nanofibers onto collagen surgical sutures. Drugs like flurbiprofen (FLU) and acetylsalicylic acid (ASA) were loaded onto PEG/HPC/UR nanofiber membranes to reduce inflammation, infection, and swelling associated with surgical procedures. Overall, this study uses a simple one-step method, without requiring any additional complex processes, and ethanol as the solvent, to enable PEG nanofiber membranes to possess controlled drug release, enhanced antibacterial properties, and improved stress–strain performance.</p> Graphical abstract <p></p>

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High stretch deformation and drug release nanofiber membrane made from hydroxypropyl cellulose and urushiol-modified polyethylene glycol

  • 期刊论文

  • 发表日期：

    2025年9月23日

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  • Hui Li,
  • Mengdan Wei,
  • Sen Li,
  • Qian-Yu Yuan,
  • Shihan Wulin,
  • Bing-Chiuan Shiu

摘要

We investigated the enhancement of the mechanical and functional properties of polyethylene glycol (PEG)-based nanofiber membranes for wound dressing applications. By incorporating hydroxypropyl cellulose (HPC) and using ethanol as the solvent, we improved the stress–strain performance of PEG/HPC nanofiber membranes by over 30% compared to pure PEG membranes. This modification effectively addresses the issue of insufficient extensibility in PEG-based membranes, a critical factor for their use in wound care. Furthermore, to overcome the challenge of rapid drug release, we introduced urushiol (UR), a natural compound extracted from lacquer trees, as both a sustained-release and antibacterial agent. This addition enhances the release profile and provides antibacterial properties. Furthermore, the incorporation of  1 wt% nano-zinc oxide significantly boosted the antibacterial efficacy, achieving over 95% inhibition. For greater material versatility, double conjugate electrospinning was employed to coat the nanofibers onto collagen surgical sutures. Drugs like flurbiprofen (FLU) and acetylsalicylic acid (ASA) were loaded onto PEG/HPC/UR nanofiber membranes to reduce inflammation, infection, and swelling associated with surgical procedures. Overall, this study uses a simple one-step method, without requiring any additional complex processes, and ethanol as the solvent, to enable PEG nanofiber membranes to possess controlled drug release, enhanced antibacterial properties, and improved stress–strain performance.

Graphical abstract