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<p>Through dopaminergic neurodegeneration and oxidative stress, long-term exposure to the synthetic pyrethroid pesticide cypermethrin has been epidemiologically associated with a higher risk of Parkinson’s disease. Through the gut-brain axis, cypermethrin and its neurotoxic metabolites are broken down by the human gut microbiome which may lower the risk of Parkinson’s disease. With the help of three vital enzymes—carboxylesterase, dioxygenase and monooxygenase—<i>Lacticaseibacillus paracasei</i> breaks down cypermethrin into its non-toxic forms which are phenol and catechol. The suggested model for cypermethrin biodegradation was clarified using a systems biology approach with CellDesigner. By mimicking cofactors that are important in the bacterial breakdown of cypermethrin, this study postulated the degradation process. <i>L.paracasei</i>,because of its metabolic adaptability and ability to metabolize xenobiotics, it is favoured as a possible microbial marker. According to the simulation results, cypermethrin degradation is accelerated by higher oxygen concentrations and NADPH serves as the pathways reducing agent. The LD<sub>50</sub> value of cypermethrin absorbed in the body was taken into account when performing simulations for both genders at average weights. This integrated approach shows great promise for detoxifying the environment using gut microbiome and systems biology tools, opening up new avenues for microbial-based methods to lessen the ecological impacts of synthetic pesticides. This method shows how altering the composition and function of the gut microbiota may be a preventive measure against Parkinson’s disease-related neurodegeneration brought on by pesticides.</p>

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Elucidation of cypermethrin degradation pathway by human gut microbiome in controlling risk for parkinson’s disease- a systems biology approach

  • 期刊论文

  • 发表日期：

    2026年1月8日

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  • Tanush P. Harish,
  • Sayim Ali Akbara,
  • H. V. Anusha,
  • Sasmita Sabat

摘要

Through dopaminergic neurodegeneration and oxidative stress, long-term exposure to the synthetic pyrethroid pesticide cypermethrin has been epidemiologically associated with a higher risk of Parkinson’s disease. Through the gut-brain axis, cypermethrin and its neurotoxic metabolites are broken down by the human gut microbiome which may lower the risk of Parkinson’s disease. With the help of three vital enzymes—carboxylesterase, dioxygenase and monooxygenase—Lacticaseibacillus paracasei breaks down cypermethrin into its non-toxic forms which are phenol and catechol. The suggested model for cypermethrin biodegradation was clarified using a systems biology approach with CellDesigner. By mimicking cofactors that are important in the bacterial breakdown of cypermethrin, this study postulated the degradation process. L.paracasei,because of its metabolic adaptability and ability to metabolize xenobiotics, it is favoured as a possible microbial marker. According to the simulation results, cypermethrin degradation is accelerated by higher oxygen concentrations and NADPH serves as the pathways reducing agent. The LD50 value of cypermethrin absorbed in the body was taken into account when performing simulations for both genders at average weights. This integrated approach shows great promise for detoxifying the environment using gut microbiome and systems biology tools, opening up new avenues for microbial-based methods to lessen the ecological impacts of synthetic pesticides. This method shows how altering the composition and function of the gut microbiota may be a preventive measure against Parkinson’s disease-related neurodegeneration brought on by pesticides.