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<p>Lung cancer remains the leading cause of cancer-related mortality worldwide, with squamous cell carcinoma (SCC) ranking as the second most common subtype of non-small cell lung cancer (NSCLC). While distant metastasis is frequently observed in lung cancer, isolated renal metastasis is extremely uncommon. We report a case of a 33-year-old never-smoking female diagnosed with lung SCC, initially treated with neoadjuvant chemotherapy followed by curative surgery. After three years of disease-free status, routine follow-up imaging revealed a solitary renal mass, which was confirmed as metastatic lung SCC through histopathological and immunohistochemical analysis. Molecular analysis demonstrated the presence of an epidermal growth factor receptor (EGFR) exon 19 deletion mutation. The patient underwent partial nephrectomy, and targeted therapy with an EGFR inhibitor was initiated. This case underscores the importance of vigilant long-term follow-up in lung cancer survivors, as renal metastases often remain asymptomatic and are incidentally detected. Given the rarity of isolated renal metastases, no standardized guidelines exist for management, though surgical resection combined with systemic therapy appears beneficial in select cases. Further studies are needed to establish optimal treatment guidelines and assess the role of emerging therapies in managing solitary renal metastases from lung SCC.</p>

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Solitary isolated renal metastasis from lung squamous cell carcinoma: a case report and comprehensive review of the literature

  • 期刊论文

  • 发表日期：

    2026年7月20日

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  • Sharareh Seifi,
  • Sara Shiari,
  • Mihan Pourabdollah,
  • Seyedeh Faezeh Sadatkiaei,
  • Mohsen Salimi

摘要

Lung cancer remains the leading cause of cancer-related mortality worldwide, with squamous cell carcinoma (SCC) ranking as the second most common subtype of non-small cell lung cancer (NSCLC). While distant metastasis is frequently observed in lung cancer, isolated renal metastasis is extremely uncommon. We report a case of a 33-year-old never-smoking female diagnosed with lung SCC, initially treated with neoadjuvant chemotherapy followed by curative surgery. After three years of disease-free status, routine follow-up imaging revealed a solitary renal mass, which was confirmed as metastatic lung SCC through histopathological and immunohistochemical analysis. Molecular analysis demonstrated the presence of an epidermal growth factor receptor (EGFR) exon 19 deletion mutation. The patient underwent partial nephrectomy, and targeted therapy with an EGFR inhibitor was initiated. This case underscores the importance of vigilant long-term follow-up in lung cancer survivors, as renal metastases often remain asymptomatic and are incidentally detected. Given the rarity of isolated renal metastases, no standardized guidelines exist for management, though surgical resection combined with systemic therapy appears beneficial in select cases. Further studies are needed to establish optimal treatment guidelines and assess the role of emerging therapies in managing solitary renal metastases from lung SCC.