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<p>Extramammary Paget’s disease (EMPD) is a rare intraepithelial adenocarcinoma. EMPD can be associated with an underlying malignancy of an adjacent organ, in which case the skin lesion is known as the pagetoid spread (PS) of the underlying tumor. PS, also known as secondary EMPD, has a worse prognosis than primary EMPD. The standard treatment is surgery, but the efficacy of nonsurgical treatments is unknown in inoperable cases. We present 2 cases of anal canal adenocarcinoma with PS that were treated with definitive concurrent chemoradiation therapy (CCRT). Although both cases experienced recurrence outside of the radiation field, and one died, anal function was preserved in both. In conclusion, CCRT may be a viable treatment option for inoperable anal canal cancer with PS.</p>

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Good local control acquired by chemoradiation for inoperable adenocarcinoma of the anal canal with pagetoid spread: a report of two cases

  • 期刊论文

  • 发表日期：

    2025年9月29日

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  • Yukako Kida,
  • Itaru Ikeda,
  • Masahiro Yamada,
  • Tomoyuki Goto,
  • Junpei Yonemaru,
  • Shuang Zhang,
  • Yoshiyuki Watanabe,
  • Chikako Yamauchi

摘要

Extramammary Paget’s disease (EMPD) is a rare intraepithelial adenocarcinoma. EMPD can be associated with an underlying malignancy of an adjacent organ, in which case the skin lesion is known as the pagetoid spread (PS) of the underlying tumor. PS, also known as secondary EMPD, has a worse prognosis than primary EMPD. The standard treatment is surgery, but the efficacy of nonsurgical treatments is unknown in inoperable cases. We present 2 cases of anal canal adenocarcinoma with PS that were treated with definitive concurrent chemoradiation therapy (CCRT). Although both cases experienced recurrence outside of the radiation field, and one died, anal function was preserved in both. In conclusion, CCRT may be a viable treatment option for inoperable anal canal cancer with PS.