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<p>Papillary tumors of the pineal region (PTPR) are rare neoplasms arising from pineal gland and occurring in less than 1% of adult patients. Surgery is reported as the main treatment option, although the role of radiotherapy, especially in the adjuvant setting, remains controversial. A young adult woman of 24&#xa0;years received adjuvant radiotherapy after a subtotal resection of a PTPR. The patient was treated with helical tomotherapy for a total dose of 59.4&#xa0;Gy delivered in 33 fractions with no concurrent chemotherapy. After initial follow-up MRI exams documented stable disease, later imaging reported a slight decrease in size of the treated lesion. After 2 years of follow-up the patient is in good general conditions, with no evidence of recurrence, and no major side effects from the treatment. This descriptive case highlights the role of adjuvant radiotherapy as a safe and effective treatment option to reduce the risk of local recurrence. Modern radiotherapy techniques may easily allow the delivery of higher doses to the target to reduce the incidence of disease relapse.</p>

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Adjuvant radiotherapy for papillary tumor of the pineal region: a case report with a narrative review of the literature

  • 期刊论文

  • 发表日期：

    2025年9月1日

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  • Francesco Cuccia,
  • Gianluca Mortellaro,
  • Marco Messina,
  • Giovanni Tringali,
  • Giuseppe Craparo,
  • Giuseppina Iacoviello,
  • Livio Blasi,
  • Giuseppe Carruba,
  • Giuseppe Ferrera

摘要

Papillary tumors of the pineal region (PTPR) are rare neoplasms arising from pineal gland and occurring in less than 1% of adult patients. Surgery is reported as the main treatment option, although the role of radiotherapy, especially in the adjuvant setting, remains controversial. A young adult woman of 24 years received adjuvant radiotherapy after a subtotal resection of a PTPR. The patient was treated with helical tomotherapy for a total dose of 59.4 Gy delivered in 33 fractions with no concurrent chemotherapy. After initial follow-up MRI exams documented stable disease, later imaging reported a slight decrease in size of the treated lesion. After 2 years of follow-up the patient is in good general conditions, with no evidence of recurrence, and no major side effects from the treatment. This descriptive case highlights the role of adjuvant radiotherapy as a safe and effective treatment option to reduce the risk of local recurrence. Modern radiotherapy techniques may easily allow the delivery of higher doses to the target to reduce the incidence of disease relapse.