Purpose of Review <p>To summarize the available knowledge on the effect of eating frequency and intermittent fasting to prevent and manage obesity.</p> Recent Findings <p>Eating schedule variability is associated with excess weight. Increasing eating frequency in those who eat three times a day or less does not lead to weight reduction. Intermittent fasting diets may enhance lipolysis, insulin sensitivity, adipose remodeling, and restore gut microbial diversity. Intermittent fasting diets appeared more effective than unrestricted diets and non-inferior to continuous energy restriction in producing weight loss. Intermittent fasting diets appeared more effective than unrestricted diets and non-inferior to continuous energy restriction in producing weight loss. Intermittent fasting may provide some additional benefits for lipid profiles, glucose control, and liver steatosis, but not for blood pressure. Possible benefits on gingival inflammation and detrimental effects on hair growth should warrant further investigation.</p> Summary <p>Reduced eating frequency and intermittent fasting diets are effective lifestyle interventions for weight loss. The preference for intermittent fasting over continuous energy restriction should depend on the patient to maximize adherence.</p> Graphical Abstract <p></p>