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Objective <p>The purpose of this study is to evaluate the additional effect of exercise to intermittent fasting (IF) on body composition and cardiometabolic health in adults with overweight/obesity.</p> Method <p>Relevant studies were identified through a systematic search across five databases. A random-effects meta-analysis was conducted on outcomes including body composition and cardiometabolic health markers, to compare the effect of combining IF with exercise against IF alone. The certainty of the evidence was evaluated using the GRADE approach, while the quality of the included studies was assessed using the revised Cochrane risk-of-bias tool and the TESTEX scale.</p> Result <p>In total, twelve studies including 616 participants (Age: 40 ± 9&#xa0;years; BMI: 33.6 ± 4.8&#xa0;kg/m<sup>2</sup>; 87.3% female) were included in this systematic review and meta-analysis. The combined intervention was more effective, leading to greater reductions in fat mass (-0.93&#xa0;kg [95% CI: -1.69, -0.18]) and waist circumference (-2.51&#xa0;cm [95% CI: -3.70, -1.32]) when compared to IF alone. Cardiometabolic health parameters also showed greater improvements, with decreased insulin (-3.1uIU/ml [95%CI: -4.25; -1.95]), HOMA-IR (-0.57 [95%CI: -0.83; -0.31]), LDL (-10.67&#xa0;mg/dl [95%CI: -20; -1.35]), resting heart rate (-2.68&#xa0;bpm [95%CI: -4.71; -0.64]), along with enhanced cardiorespiratory fitness (VO<sub>2 max</sub>:1.92&#xa0;ml/kg/min [95%CI: 0.32; 3.52]). For the remaining outcome variables, no statistically meaningful differences emerged between the groups.</p> Conclusion <p>The potential benefits of incorporating exercise into IF for adults with overweight/obesity, particularly in terms of body composition, glycemic control, and cardiorespiratory fitness, appear promising. Nevertheless, given the limited amount of data, future investigations are essential to strengthen the evidence base and investigate the influence of specific exercise and IF types in enhancing treatment outcomes.</p> <p><b>Registry and registry number for systematic reviews or meta-analyses:</b> CRD42024550753.</p>

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Additional Effect of Exercise to Intermittent Fasting on Body Composition and Cardiometabolic Health in Adults With Overweight/obesity: A Systematic Review and Meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月19日

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  • Zi-han Dai,
  • Ke-wen Wan,
  • Po-san Wong,
  • Wendy Yajun Huang,
  • Angus Pak-hung Yu,
  • Stephen Heung-sang Wong

摘要

Objective

The purpose of this study is to evaluate the additional effect of exercise to intermittent fasting (IF) on body composition and cardiometabolic health in adults with overweight/obesity.

Method

Relevant studies were identified through a systematic search across five databases. A random-effects meta-analysis was conducted on outcomes including body composition and cardiometabolic health markers, to compare the effect of combining IF with exercise against IF alone. The certainty of the evidence was evaluated using the GRADE approach, while the quality of the included studies was assessed using the revised Cochrane risk-of-bias tool and the TESTEX scale.

Result

In total, twelve studies including 616 participants (Age: 40 ± 9 years; BMI: 33.6 ± 4.8 kg/m2; 87.3% female) were included in this systematic review and meta-analysis. The combined intervention was more effective, leading to greater reductions in fat mass (-0.93 kg [95% CI: -1.69, -0.18]) and waist circumference (-2.51 cm [95% CI: -3.70, -1.32]) when compared to IF alone. Cardiometabolic health parameters also showed greater improvements, with decreased insulin (-3.1uIU/ml [95%CI: -4.25; -1.95]), HOMA-IR (-0.57 [95%CI: -0.83; -0.31]), LDL (-10.67 mg/dl [95%CI: -20; -1.35]), resting heart rate (-2.68 bpm [95%CI: -4.71; -0.64]), along with enhanced cardiorespiratory fitness (VO2 max:1.92 ml/kg/min [95%CI: 0.32; 3.52]). For the remaining outcome variables, no statistically meaningful differences emerged between the groups.

Conclusion

The potential benefits of incorporating exercise into IF for adults with overweight/obesity, particularly in terms of body composition, glycemic control, and cardiorespiratory fitness, appear promising. Nevertheless, given the limited amount of data, future investigations are essential to strengthen the evidence base and investigate the influence of specific exercise and IF types in enhancing treatment outcomes.

Registry and registry number for systematic reviews or meta-analyses: CRD42024550753.