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Purpose of Review <p>Serum markers are valuable tools in the inpatient setting, providing objective metrics to support clinical diagnosis, disease monitoring, and therapeutic decisions. In this review, we highlight twelve established serum markers for skin disease management -- categorized into infectious, inflammatory, and neoplastic groups -- each offering distinct clinical utility and limitations.</p> Recent Findings <p>Infectious markers -- including antistreptolysin O (ASO)/anti-DNase B (ADB), β-D-glucan (BDG), galactomannan (GM), non-treponemal tests, treponemal tests, and procalcitonin (PCT) – can be particularly useful in aiding diagnosis of skin-related infections. Inflammatory markers such as ferritin, IL-6, IL-17, IgE, and BP180 autoantibodies offer insights into inflammatory and autoimmune conditions. Neoplastic markers -- such as lactate dehydrogenase (LDH) and Anti-Merkel cell polyomavirus (AMERK) antibodies -- offer significant prognostic insights.</p> Summary <p>This review covers twelve serum markers of either infectious, inflammatory, or neoplastic utility for skin conditions in the inpatient setting. Ultimately, thoughtful incorporation and cautious interpretation of serum biomarkers can significantly improve diagnostic accuracy, therapeutic decision-making, and patient outcomes in inpatient practice relating to skin conditions and enhance the care of patients with dermatologic disease.</p>

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Key Serum Markers for Infectious, Inflammatory, and Neoplastic Skin-Related Conditions for the Inpatient Dermatologist and Internist

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • Ruhi Kanwar,
  • Ryan Chen,
  • Elene Tsopurashvili,
  • Mihir K. Patil,
  • Thomas Z. Rohan,
  • Richard Tran,
  • David Wang,
  • Vinod E. Nambudiri

摘要

Purpose of Review

Serum markers are valuable tools in the inpatient setting, providing objective metrics to support clinical diagnosis, disease monitoring, and therapeutic decisions. In this review, we highlight twelve established serum markers for skin disease management -- categorized into infectious, inflammatory, and neoplastic groups -- each offering distinct clinical utility and limitations.

Recent Findings

Infectious markers -- including antistreptolysin O (ASO)/anti-DNase B (ADB), β-D-glucan (BDG), galactomannan (GM), non-treponemal tests, treponemal tests, and procalcitonin (PCT) – can be particularly useful in aiding diagnosis of skin-related infections. Inflammatory markers such as ferritin, IL-6, IL-17, IgE, and BP180 autoantibodies offer insights into inflammatory and autoimmune conditions. Neoplastic markers -- such as lactate dehydrogenase (LDH) and Anti-Merkel cell polyomavirus (AMERK) antibodies -- offer significant prognostic insights.

Summary

This review covers twelve serum markers of either infectious, inflammatory, or neoplastic utility for skin conditions in the inpatient setting. Ultimately, thoughtful incorporation and cautious interpretation of serum biomarkers can significantly improve diagnostic accuracy, therapeutic decision-making, and patient outcomes in inpatient practice relating to skin conditions and enhance the care of patients with dermatologic disease.